Chimerism in health, transplantation and autoimmunity Koopmans, M.; Kremer Hovinga, I.C.L.

The third hypothesis is that the chimeric cell is not directly involved in the pathogenesis of autoimmune disease, but that its presence in host tissues represents the result of a

Chimerism was found signifi cantly more often in organs from patients with SLE that experienced injury compared with normal control organs, irrespective of whether the injury was

Therefore, in the present study we investigated the presence of chimerism in a new group of women with proliferative lupus nephritis, of whom extensive information on

In this study, we investigated the presence of Y chromosome-positive chimeric cells in uteri of women with SLE and of normal women, and we found that signifi cantly more uteri of

To determine the role of chimerism in human SLE, we previously investigated the presence of chimerism in kidney biopsies of adult women with lupus nephritis and found that

In conclusion, in this thesis we demonstrate that chimerism is not restricted to the blood of healthy individuals, but can also occur in healthy hearts, lungs, livers, kidneys,

HCG Human choriogonadotropin HE hematoxylin and eosin HLA Human leukocyte antigen HRP Horseradish peroxidase HVG Host versus graft HVGD Host versus graft disease IG

From February 2004 until September 2006 she worked full time at the department of Pathology of the Leiden University Medical Center on the studies described in this thesis..