Cover Page
The handle
http://hdl.handle.net/1887/78663
holds various files of this Leiden University
dissertation.
Author: Meessen, J.M.T.A.
Title: Outcome of osteoarthritis and arthroplasty from patient perspective to molecular
profiling.
Outcome of osteoarthritis and arthroplasty
PhD thesis, Leiden University Medical Center, Leiden, The Netherlands.
Copyright 2019 J.M.T.A. Meessen, Leiden, the Netherlands.
All rights reserved. No part of this book may be reproduced in any form without written permission of the author.
Cover drawing: Mai Tran
Outcome of osteoarthritis and arthroplasty
from patient perspective to molecular profiling.
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van Rector Magnificus Prof. Mr C.J.J.M.Stolker
volgens besluit van het College voor Promoties
te verdedigen op donderdag 26 september 2019
Klokke 11:15 uur
door
Promotores
Prof. Dr. R.G.H.H. Nelissen
Prof. P.E. Slagboom
Promotiecommissie
Prof. Dr T. P. M. Vliet Vlieland
Prof. Dr. J. Gussekloo
Prof. Dr. J. A. N. Verhaar
Department of Orthopedics
Erasmus Medisch Centrum
Rotterdam
Dr. H. C. Willems, PhD
Department of Internal Medicine & Geriatrics
Amsterdam Universitair Medisch Centrum
Table of Contents:
Chapter 1: page 1
Introduction
Chapter 2: page 13
Increased mortality in metal-on-metal versus non-metal on metal primary total hip arthroplasty at 10 years and longer follow-up: a systematic review and meta-analysis.
Chapter 3: page 37
Patients who underwent total hip or knee arthroplasty are more physically active than the general Dutch population.
Chapter 4: page 55
Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire.
Chapter 5: page 69
Frailty questionnaire is no predictor for functional outcomes in hip or knee arthroplasty patients.
Chapter 6: page 85
Association of handgrip strength with patient reported outcome measures after total hip and knee arthroplasty.
Chapter 7: page 99
The BBMRI metabolomics consortium: plasma histidine, glutamine and fatty acid make-up associate with prevalence and progression of knee and hip osteoarthritis.
Chapter 8: page 127
Summary & Discussion
Chapter 9: page 141
Appendixes
Nederlandse samenvatting page 142
Riassunto in italiano page 147
Curriculum vitae page 153
List of publications page 154
