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Contents

CONTENTS

Chapter 1 General introduction General introduction General introduction General introduction

Chapter 2 Role of interleukin Role of interleukin----6 Role of interleukin Role of interleukin 6 6 6 in mediating mesangial cell in mediating mesangial cell in mediating mesangial cell in mediating mesangial cell proliferation and matrix production in vivo

proliferation and matrix production in vivo proliferation and matrix production in vivo proliferation and matrix production in vivo Kidney international 51: 69-78, 1997

Chapter 3 Distinctive roles of neutrophils and Distinctive roles of neutrophils and Distinctive roles of neutrophils and Distinctive roles of neutrophils and monocytes in anti

monocytes in anti monocytes in anti

monocytes in anti----Thy Thy Thy----1 nephritis Thy 1 nephritis 1 nephritis 1 nephritis American Journal of Pathology 156: 303–310, 2000

Chapter 4 Hu Human mesangial cells in culture and in kidney Hu Hu man mesangial cells in culture and in kidney man mesangial cells in culture and in kidney man mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89) sections fail to express Fc alpha receptor (CD89) sections fail to express Fc alpha receptor (CD89) sections fail to express Fc alpha receptor (CD89) Journal of the American Society of

Nephrology 10: 770-778, 1999

Chapter 5 A novel receptor for IgA expressed A novel receptor for IgA expressed A novel receptor for IgA expressed A novel receptor for IgA expressed On human renal mesangial cells On human renal mesangial cells On human renal mesangial cells On human renal mesangial cells Submitted

Chapter 6 Crosslinking of the human Fc receptor for IgA Crosslinking of the human Fc receptor for IgA Crosslinking of the human Fc receptor for IgA Crosslinking of the human Fc receptor for IgA (Fc

(Fc (Fc

(FcααααRI/CD89) triggers FcR RI/CD89) triggers FcR RI/CD89) triggers FcR γγγγ----chain RI/CD89) triggers FcR chain chain----dependent chain dependent dependent dependent shedding of soluble CD89

shedding of soluble CD89 shedding of soluble CD89 shedding of soluble CD89

Journal of Immunology 163: 5806-5812, 1999

Chapter 7 General discussion and Summary General discussion and Summary General discussion and Summary General discussion and Summary Samenvatting

Samenvatting Samenvatting Samenvatting Curriculum Curriculum vitae Curriculum vitae Curriculum vitae vitae Acknow Acknow Acknowledgements Acknow ledgements ledgements ledgements

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Abbreviations

ABBREVIATIONS

aa amino acid

ADCC Antibody-Dependent Cellular Cytotoxicity aIgA heat aggregated IgA

Ag Antigen

ASPG-R Asialo-Glyco-Protein Receptor bp base pare

bFGF basic fibroblast growth factor cDNA complementary DNA C3 Complement component 3 C6 Complement component 6 dIgA dimeric IgA

EC Extra Cellular

EDTA Ethylene-Diamine-Tetra-acetic-Acid FACS Fluorescence Activated Cell Sorter Fab’ Fragment antigen binding

Fc crystallizable Fragment FCS Fetal Calf Serum FcR Fc Receptor FcαR IgA Fc Receptor FcγR IgG Fc Receptor FcεR IgE Fc Receptor

FITC fibrinogen-fluorescein isothiocyanate IC Immune Complex

IgA Immunoglobuline A IgAN IgA Nephropathy IgG Immunoglobuline G IgM Immunoglobuline M IL Interleukine

ILT Ig-Like Transcript receptor

ITAM Immunoreceptor Tyrosine-based Activation Motif ITIM Immunoreceptor Tyrosine-based Inhibition Motif kD kilo Dalton

KIR Killer cell Inhibitory Receptor

LAIR Leukocyte-Associated Immunoglobuline-like Receptor LIR Leukocyte Ig-like Receptor

mAb monoclonal Antibody MC Mesangial Cell

MCP-1 Monocyte Chemoattractant Peptide-1 MFI Mean Fluorescence Intensity

mIgA monomeric IgA

MIR Monocyte/Macrophage Ig-like Receptor Ms Mouse

PBS Phosphate Buffered Saline PCNA proliferating cell nuclear antigen pIgA polymeric IgA

PIR Paired Ig-like Receptor PMN Poly-Morpho-Nuclear cell Rb Rabbit

TGF Transforming Growth Factor TNF Tumor Necrosis Factor

Referenties

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