The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/68703
Author: Zwiers, C.
HEMOLYTIC DISEASE OF THE FETUS
AND NEWBORN
Cover illustration Carole Matthijsse Illustration Intrauterine transfusion illustration Gautier Illustration
Layout Ilse Stronks, persoonlijkproefschrift.nl Printing Ridderprint BV | www.ridderprint.nl The research described in this thesis was funded by Sanquin Blood Supply. This financial support did not interfere with the conduct of results of the studies.
HEMOLYTIC DISEASE OF THE FETUS
AND NEWBORN
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 12 maart 2019
klokke 16.15 uur door
Carolien Zwiers
Copromotor: Dr. I.L. van Kamp
Leden promotiecommissie: Prof. dr. J.J. Zwaginga
Prof. dr. E. Pajkrt, Amsterdam University
Medical Center
TABLE OF CONTENTS
PART 1: OVERVIEW
General Introduction 7
Chapter 1 Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn - review on current management and outcome
17
PART 2: PATHOGENESIS AND SEVERITY OF HEMOLYTIC DISEASE OF THE FETUS AND NEWBORN
Chapter 2 ABO incompatibility and RhIg immunoprophylaxis protect against non-D alloimmunization by pregnancy
31
Chapter 3 Does disease severity always increase in subsequent pregnancies with D immunization?
53
Chapter 4 The near disappearance of fetal hydrops in relation to current state-of-the-art management of red cell alloimmunization
75
PART 3: INTRAUTERINE TRANSFUSION AND OTHER TREATMENT OPTIONS
Chapter 5 Complications of intrauterine intravascular blood transfusion: lessons learned after 1678 procedures
91
Chapter 6 Postponing Early intrauterine Transfusion with Intravenous immunoglobulin Treatment; the PETIT study on severe hemolytic disease of the fetus and newborn
105
Chapter 7 Immunoglobulin for alloimmune hemolytic disease in neonates – a Cochrane review
125
PART 4: SUMMARY AND DISCUSSION
Summary and General Discussion 163
Epilogue 170
List of abbreviations 184
