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Human enteroviruses and parechoviruses: disease spectrum and need for
treatment in young children
Wildenbeest, J.G.
Publication date
2014
Document Version
Final published version
Link to publication
Citation for published version (APA):
Wildenbeest, J. G. (2014). Human enteroviruses and parechoviruses: disease spectrum and
need for treatment in young children.
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Human enteroviruses and parechoviruses:
disease spectrum and need for treatment
in young children
Joanne G. Simons-Wildenbeest
Human en
ter
oviruses and par
echo
viruses: disease spectrum and need f
or tr ea tmen t in y oung childr en Joanne G. Simons -Wildenbees t
Uitnodiging
voor het bijwonen van de openbare verdediging van
het proefschrift
Human enteroviruses
and parechoviruses:
disease spectrum and
need for treatment
in young children
door Joanne G. Simons-Wildenbeest Donderdag 18 december 2014 om 10.00 uur in de Agnietenkapel, Oudezijds Voorburgwal 229-231 te Amsterdam Receptie na afloop van de promotie U bent tevens van harte uitgenodigd voor de promotieborrel
tussen 18.00 en 20.00 uur in de Bluespoon Bar Andaz Prinsengracht 587 Amsterdam Joanne G. Simons-Wildenbeest J.G.Wildenbeest@amc.uva.nl Paranimfen Matthijs Wildenbeest Thomas Wildenbeest promotiejoannesimons@gmail.com
Human enteroviruses and parechoviruses:
disease spectrum and need for treatment
in young children
Colofon
Cover photo by Brian Simons
Lay-out & print by Gildeprint, Enschede, the Netherlands ISBN: 978-94-6108-856-7
Printing of this thesis was financially supported by the Academic Medical Center, University of Amsterdam.
Copyright © 2014 J.G. Simons-Wildenbeest
All rights are reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without prior permission of the author, or when appropriate, of the publishers of the publications or figures.
Human enteroviruses and parechoviruses:
disease spectrum and need for treatment
in young children
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. D.C. van den Boom
ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op donderdag 18 december 2014, te 10.00 uur
door
Joanne Geraldine Wildenbeest
Promotiecommissie
Promotores: Prof. dr. M.D. de Jong Prof. dr. T.W. Kuijpers Copromotores: Dr. D. Pajkrt
Dr. K.C. Wolthers
Overige leden: Prof. dr. M. Boele van Hensbroek Prof. dr. A.H.L.C. van Kaam Prof. dr. M.P.G. Koopmans Prof. dr. J. Neyts
Prof. dr. H.L. Zaaijer Dr. L. van der Linden
در یا مدآ
درھو ز شرآ رد
رزور دروآ درد ىو و
رار د ار ھو رد
نارد ت ز و
دآ د ت د
"Humans are limbs of one body
and are created with the same valuable essence.
When one limb passes its days in pain
the other limbs will be disturbed.
You, who feel no pain at the suffering of others
deserve not to be called human."
Saadi Shirazi, Persian poet
“Humans are limbs of one body
and are created with the same valuable essence. When one limb passes its days in pain the other limbs cannot remain at rest. You, who feel no pain at the suffering of others
deserve not to be called human.”
Contents
Chapter 1 General introduction 11
PART I: Clinical relevance
Chapter 2 Rhinovirus C is not associated with wheezing or severe disease 33 in an unselected birth cohort from the Netherlands
Chapter 3 Clinical relevance of positive human parechovirus type 1 and 3 PCR 53 in stool samples
Chapter 4 Prolonged shedding of human parechovirus in feces of young children 69 after symptomatic infection
Chapter 5 Exposure to recreational and drinking water and the occurrence of 79 parechovirus and enterovirus infections in infants
PART II: Treatment options
Chapter 6 The need for treatment against human parechoviruses: how, why 89 and when?
Chapter 7 Pleconaril revisited: clinical course of chronic enteroviral 113 meningoencephalitis after treatment correlates with in vitro
susceptibility
Chapter 8 Genetic and antigenic structural characterization for resistance of 127 Echovirus 11 to pleconaril in an immunocompromised patient
Chapter 9 Successful IVIG treatment of human parechovirus-associated 147 dilated cardiomyopathy in an infant
Chapter 10 Specific cell tropism and neutralization of human parechovirus 157 types 1 and 3: implications for pathogenesis and therapy development
Chapter 11 Differences in maternal antibody protection against human 173 parechovirus types 1, 3 and 4 in young infants
PART III: Summary and Discussion
Chapter 12 Summary 193
Chapter 13 Discussion 201
Addendum List of co-authors 217 Dutch summary (Nederlandse samenvatting) 221 Acknowledgements (Dankwoord) 229
List of publications 233
Curriculum vitae 235
Portfolio 236
