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Stepping into the RING: preclinical models in the fight against hereditary breast
cancer
Drost, R.M.
Publication date
2012
Link to publication
Citation for published version (APA):
Drost, R. M. (2012). Stepping into the RING: preclinical models in the fight against hereditary
breast cancer. Het Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis.
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Table of contents
Abbreviations
Chapter 1 Preclinical mouse models for BRCA1-associated breast cancer.
Chapter 2 Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
Chapter 3 BRCA1-deficient mouse mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Chapter 4 Loss of p53 partially rescues embryonic development of
Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.
Chapter 5 BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
Chapter 6 BRCA1185delAG tumors may acquire therapy resistance through
expression of a RING-less BRCA1 protein via internal translation reinitiation.
Chapter 7 General discussion
Appendix English summary
Nederlandse samenvatting Curriculum vitae Publications Dankwoord 9 13 29 49 69 95 133 169 193 197 200 201 202
