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Addiction: A striatal roller-coaster
On the neural and associative-learning mechanisms underlying gambling and alcohol use
disorder
van Timmeren, T.
Publication date
2019
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Citation for published version (APA):
van Timmeren, T. (2019). Addiction: A striatal roller-coaster: On the neural and
associative-learning mechanisms underlying gambling and alcohol use disorder.
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ADDICTION:
A STRIATAL ROLLER-COASTER
ON THE NEURAL AND ASSOCIATIVE-LEARNING MECHANISMS
UNDERLYING GAMBLING AND ALCOHOL USE DISORDER
The research described in this thesis was financially supported by a grant of the Netherlands Organization for Scientific Research to Anna E. Goudriaan (ZonMw grant VIDI #91713354) ISBN: 978-94-6375-403-3
Cover: Roel van Timmeren
Lay-out: Nikki Vermeulen - Ridderprint Printing: Ridderprint - www.ridderprint.nl © Tim van Timmeren, 2019
ADDICTION:
A STRIATAL ROLLER-COASTER
ON THE NEURAL AND ASSOCIATIVE-LEARNING MECHANISMS
UNDERLYING GAMBLING AND ALCOHOL USE DISORDER
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 5 juli 2019, te 14.00 uur door
Tim van Timmeren
Promotiecommissie
PromotorProf. dr. A.E. Goudriaan AMC-Universiteit van Amsterdam Co-promotor
Dr. R.J. van Holst AMC-Universiteit van Amsterdam Overige leden
Prof. dr. G.A. van Wingen AMC-Universiteit van Amsterdam Prof. dr. L. Reneman AMC-Universiteit van Amsterdam Dr. S. de Wit Universiteit van Amsterdam Prof. dr. R. Cools Radboud Universiteit Nijmegen Dr. L. Clark University of British Columbia Faculteit der Geneeskunde
“Our battles with our habits speak of dreams yet to become real.”
Table of contents
Chapter 1 General Introduction 9
Chapter 2 Compulsivity-related neurocognitive performance deficits in gambling disorder: A systematic review and meta-analysis
21
Chapter 3 Goal-directed and habitual decision making under stress in Gambling Disorder
53
Chapter 4 Intact corticostriatal control of goal-directed action in human Alcohol Use Disorder: evidence from a Pavlovian-to-instrumental transfer and outcome-devaluation fMRI study
71
Chapter 5 Testing striatal ups and downs: An fMRI study on the interaction between monetary reward anticipation and cue reactivity in gambling and alcohol use disorder
93
Chapter 6 White matter integrity between left basal ganglia and left prefrontal cortex is compromised in gambling disorder
119
Chapter 7 Connectivity networks in gambling disorder: a resting-state fMRI study
135
Chapter 8 Summary and General Discussion 155
Appendix Nederlandse samenvatting 179
References 187
PhD Portfolio 209
List of publications 215
