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Human herpesvirus 8 and Kaposi's sarcoma in the Amsterdam cohort studies.
Disease association, transmission and natural history
Renwick, N.M.
Publication date
2001
Link to publication
Citation for published version (APA):
Renwick, N. M. (2001). Human herpesvirus 8 and Kaposi's sarcoma in the Amsterdam cohort
studies. Disease association, transmission and natural history.
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%i#unfimary y
Thiss thesis concerns the investigation of Human Herpesviruss 8 (HHV8) and Kaposi's sarcoma (KS) in the Amsterdamm Cohort Studies and is organised into sections onn disease association, transmission and natural history. In
Inn chapter two, HHV8 is shown to be the cause of KS in thee context of HIV-1 infection and the length of the KS freee period is dependent on the timing of HIV-1 and HHV8 infections.. The symptoms that are related to primary7
Wee evaluated risk factors for HHV8 seroposkivity at study entryy and/or HHV8 seroconversion in the cohort of homo-sexuall men in chapter five. HHV8 seroprevalence at study entryy was highest among homosexual men with positive HIV-11 status, no steady partner, Southern European or Latinn American nationality, and increased with older age andd higher number of sexual partners. HHV8 serocon-versionn was associated with oro-genital sex with more than fivefive partners, older age and HIV-1 infection.
Twoo gamma-herpesviruses, termed Chlorocebus rhadino-viruss 1 (ChRVl) and ChRV2, were found in African green monkeyss in chapter seven and phylogenetic analysis sup-portss the existence of two distinct rhadinovirus lineages in Oldd World monkeys. In chapter eight we argue that the
chapterr one, KS epidemiology and pathology are
com-paredd to studies on the seroepidemiology and pathogenesis o f H H V 8 . .
HHV88 infection are described in chapter three. KS and HHV88 are shown not to protect HIV-1 infected individuals fromm AIDS dementia complex in chapter four.
RiskRisk factors were similar in the cohort of drug users in
chapterr six; HHV8 seropositivity was associated with a
historyy of homosexual contact and Mediterranean national-ity'' among male drug users and related to a history of sexual contactt with a bisexual man, absence of a steady partner and commerciall umprotected sex among female drug users. HHV88 seropositivity was not associated with injection-drug usee or infection with HIV-1, Hepatitis B virus or Hepatitis C. .
seroconversionn events to HHV8 ORF65 and ORF73 anti-genss in the cohort of homosexual men represent primary HHV88 infection. In chapter nine we found no evidence to supportt the role of vascular endothelial growth factor in KS pathogenesis. .
