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VU Research Portal

Discordance between amyloid- PET and CSF biomarkers

Reimand, Juhan

2021

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Reimand, J. (2021). Discordance between amyloid- PET and CSF biomarkers: Clinical and pathophysiological

consequences. Ipskamp Printing.

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Discordance between amyloid-β PET and CSF

biomarkers: Clinical and pathophysiological

consequences

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The studies described in this thesis were carried out in cooperation between the Alzheimer Center Amsterdam (Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC) and Department of Health Technologies (Tallinn University of Technology). Research of the Alzheimer Center is part of the Neurodegeneration program of Amsterdam Neuroscience. Printing of this thesis was supported by Stichting Alzheimer en Neuropsychiatrie.

Cover design: Juhan Reimand Layout: Juhan Reimand

Printed by: Ipskamp Printing | proefschriften.net ISBN: 978-94-6421-237-2

© Juhan Reimand, Amsterdam, the Netherlands, 2020.

All right reserved. No parts of this thesis may be reproduced, stored or transmitted in any form or by any means without prior written permission of the copyright holder, or

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VRIJE UNIVERSITEIT

Discordance between amyloid-β PET and CSF biomarkers:

Clinical and pathophysiological consequences

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad Doctor of Philosophy aan de Vrije Universiteit Amsterdam en Tallinn University of Technology,

op gezag van de rectores magnifici prof.dr. V. Subramaniam en prof.dr. T. Land,

in het openbaar te verdedigen ten overstaan van de promotiecommissie

van de Faculteit der Geneeskunde op woensdag 12 mei 2021 om 13.45 uur

in de aula van de universiteit, De Boelelaan 1105

door Juhan Reimand geboren te Tallinn, Estland

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promotoren: prof.dr. Ph. Scheltens dr. R. Ossenkoppele prof.dr. B.N.M. van Berckel copromotoren: dr. F Bouwman

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TALLINN UNIVERSITY OF TECHNOLOGY

DOCTORAL THESIS

15/2021

Discordance between amyloid-β

PET and CSF biomarkers:

Clinical and pathophysiological

consequences

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TALLINN UNIVERSITY OF TECHNOLOGY School of Information Technologies

Department of Health Technologies

This dissertation was accepted for the defence of the degree 16/10/2020

Supervisors: Prof. Sergei Nazarenko, MD, PhD

Department of Health Technologies Tallinn University of Technology Tallinn, Estonia

Prof. Philip Scheltens, MD, PhD Faculty of Medicine

VUMC Alzheimer Center, Amsterdam UMC Vrije Universiteit Amsterdam

Amsterdam, the Netherlands

Opponents: Assoc. Prof. Pilvi Ilves, MD, PhD

Department of Radiology Institute of Clinical Medicine University of Tartu

Tartu, Estonia

Dr. Elsmarieke van de Giessen, MD, PhD Department of Nuclear Medicine

Academic Medical Center, Amsterdam UMC University of Amsterdam

Amsterdam, the Netherlands

Defence of the thesis:12/05/2021, Amsterdam

Declaration:

Hereby I declare that this doctoral thesis, my original investigation and achievement, submitted for the joint doctoral degree at Tallinn University of Technology and at Vrije Universiteit Amsterdam has not been submitted for doctoral or equivalent academic degree.

Juhan Reimand

signature

Copyright: Juhan Reimand, 2020 ISSN 2585-6898 (publication) ISSN 2585-6901 (PDF)

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TALLINNA TEHNIKAÜLIKOOL

DOKTORITÖÖ

15/2021

Amüloid-β staatuse vastuolu

PET-uuringul ning liikvorianalüüsil:

Kliiniline ja patofüsioloogiline

tähendus

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