The handle https://hdl.handle.net/1887/3147341 holds various files of this Leiden
University dissertation.
Author: Bulk, M.
Title: The iron brain: Post-mortem and in vivo imaging of iron in brain diseases
Issue Date:
2021-03-03
The Iron Brain
Post-mortem and in vivo imaging of iron in brain
diseases
No part of this thesis may be reproduced or transmitted in any form or by any means, without the prior permission of the author.
The Iron Brain
Post-mortem and in vivo imaging of iron in brain
diseases
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. dr. ir. H. Bijl,
volgens besluit van het College voor Promoties, te verdedigen op woensdag 3 maart 2021
klokke 10.00 uur
door
Marjolein Bulk
geboren te Leiderdorp in 1990
Chapters
1 Introduction . . . . 1
2 Quantitative MRI and LA-ICP-MS of iron in the frontal cortex of AD . . . . 17
3 Post-mortem MRI and histology of iron and myelin in AD . . . . 41
4 Post-mortem MRI of cortical iron reflects AD severity . . . . 73
5 Characterization of MRI contrast changes in the HD striatum . . . . 97
6 7T MRI and CSF study in HD: Rationale and design . . . . 121
7 QSM of the basal ganglia in NPSLE . . . . 137
8 Summary and Discussion . . . . 159
List of Abbreviations . . . . 175 Nederlandse samenvatting . . . . 177 List of Publications . . . . 181 Curriculum Vitae . . . . 185 Dankwoord . . . . 187 v
