Cover Page The following handle holds various files of this Leiden University dissertation: http://hdl.handle.net/1887/80840

Panel 1, macroscopy hemi thyroidectomy right; Panel II and III, hematoxylin and eosin stain (HE) (×25 /×200) showing hyperplastic thyroid nodule with a somatic DICER1 RNase IIIb

Previous studies have relied mainly on candidate-gene approaches in selected patients, approaches which are, by design, limited. With the introduction of next-generation

Synthesis of ADP-ribosylated asparagine as a stabilized isostere of ADPr-Asp for structural studies of macrodomains. Chapter 7

Therefore, attention has been focused on the synthesis of suitably protected ribosylated amino acid building blocks that can be applied in a solid phase peptide

freshly activated molecular sieves and dry DMF (0.5 mL) were added and the activator solution was stirred at room temperature for 2 hours under N 2. The reaction was quenched

Dialysis using a 3.5-5 kD MWCO dialysis device removed traces of excess ADPr-propargyl reagent as well as copper/ligand/ascorbate from the reaction, followed by size

Chapter 3 describes the solid-phase synthesis of 3’,5’-pyrophosphate-linked thymidine oligomers, using a new phosphoramidite thymidine building block with an Fm protected

Chinese Summary 150