Cover Page
The handle http://hdl.handle.net/1887/65502 holds various files of this Leiden University
dissertation.
Author: Saadah, N.H.
Title: Hemovigilance, heterogeneity, and hyperfibrinolysis : evaluating the Netherlands'
switch to solvent/detergent plasma
Issue Date: 2018-09-11
Hemovigilance, heterogeneity, and hyperfibrinolysis –
evaluating the Netherlands’ switch to
solvent/detergent plasma
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op
dinsdag 11 september 2018, klokke 11:15 uur
Nicholas H. Saadahdoor geboren te Oklahoma City, USA
PROMOTOR
Prof. dr. J.G. van der Bom (Leiden University Medical Center)
CO-PROMOTOR
Dr. M.R. Schipperus (Haga Teaching Hospital)
LEDEN PROMOTIECOMMISSIE
Prof. dr. J.J. Zwaginga (Leiden University Medical Center) Prof. dr. K. Meijer (University Medical Center Groningen) Prof. dr. J.C.M. Meijers (University Medical Center Amsterdam)
Cover art: Heather Divoky www.heatherdivoky.com
Cover photo inset: Hubble Deep Field 1995 image source: NASA public archive
In December of 1995, the Hubble Space Telescope held its orientation fixed for ten days and focused on
an unremarkable, seemingly empty point of space – smaller than the period at the bottom of this page with this book held at arm’s length. The resulting long
exposure, the famous Hubble Deep Field image, is the cover image inset. Each of the thousands of light
clusters in the picture is a galaxy with hundreds of millions of stars, most of which have orbiting planets.
Earning a PhD in clinical epidemiology and becoming good at one specific part of it has left me feeling
smaller in the grand scheme and in awe of how much more there is to learn.
That in mind, consider that the scene on the front
cover surrounds us 24 million
times over
...
.
Author’s notes
Statistical notation and language (American vs. British English) differ between chapters, corresponding to the linguistic and formating styles of their journals of publication. Supplemental material referenced in unpublished chapters is available upon request from the author (saadah@alumni.stanford.edu).
Printing costs generously subsidized by Sanquin and LUMC
This research is the result of a working partnership between Sanquin, the nation’s blood supplier, and TRIP (Transfusie- en transplantatieReacties In Patiënten), the national bio- and hemovigilance office of the Netherlands. It was made possible by a grant from Sanquin, funding four years of independent PhD research at Sanquin’s Center for Clinical Transfusion Research (CCTR) in partnership with the department of Clinical Epidemiology at the Leiden University Medical Center (LUMC). Advisorship was provided by Prof. J.G.
(Anske) van der Bom (head, CCTR; professor, LUMC) and Dr. Martin Schipperus (hematologist, Haga teaching hospital; chairman, TRIP).
Chapter 1 3 Introduction
Chapter 2 9
FROSTED study
Transition from fresh frozen plasma to solvent/detergent plasma in the Netherlands: comparing clinical use and transfusion reaction risks
Chapter 3 25
TEG study
Effect of solvent/detergent treated pooled plasma on fibrinolysis in reconstituted whole blood
Chapter 4 43
Meta-analysis
Comparing transfusion reaction rates for various plasma types:
a systematic review and meta-analysis/regression
Chapter 5 63
ISTARE study
Comparing transfusion reaction incidences of various plasma products – an analysis of seven years of ISTARE haemovigilance data
Chapter 6 79
Methodological study
Comparison of various methods in meta-analysis of sparse count data – addressing the challenges of analyzing hemovigilance datasets
Chapter 7 95
Discussion
Closing 117
Nederlandse samenvatting Curriculum vitae
Acknowledgments
