Mannose-binding lectin: The Dr. Jekyll and Mr. Hyde of the innate
immune system.
Bouwman, L.H.
Citation
Bouwman, L. H. (2006, January 25). Mannose-binding lectin: The Dr. Jekyll and Mr. Hyde
of the innate immune system. Retrieved from https://hdl.handle.net/1887/4277
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
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MANNOSEBINDING LECTIN:
The Dr. Jekyll and Mr. Hyde
of the Innate Im m une System
Cover: “Dr. Jekyll and Mr. Hyde” by Marjolein Erkelens.
P rinting of th is th esis w as fi nanc ially su p p orted by th e Diabetes F onds, J.E. Ju rriaanse S tic h ting , Dr. Ir. van de L aar S tic h ting , K CI Medic al B V , B iom et N ederland B V , B oeh ring er Ing elh eim , Jag i B V , B iosienc e N L , Eth ic on P rodu c ts.
MANNOSEBINDING LECTIN:
The Dr. Jekyll and Mr. Hyde
of the Innate Immune System
Proefschrift
ter verkrijging van
de graad van Doctor aan de U niversiteit Leiden, op gez ag van de R ector Magnifi cus Dr.D.D.Breimer,
hoogleraar in de faculteit der W iskunde en Natuurwetenschappen en die der G eneeskunde,
volgens besluit van het College voor Promoties te verdedigen op woensdag 2 5 januari 2 006
klokke 15.15 uur
door
L ee H a n s B ou w m a n
PROMOTIECOMMISSIE:
Promotor: Prof. Dr. O.T. Terpstra
C o-p romotores: Dr. B.O. Roep Dr. A . Roos
R eferent: Dr. P. Garred (Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark)
O v erig e led en: Prof. Dr. J.H. van Bockel Prof. Dr. M.J. Giphart
Prof. Dr. J.N. IJzermans (Erasmus MC, Rotterdam)
The Wisdom of a Bad Memory
Always remember to forget The things that made you sad. But never forget to remember The things that made you glad. Always remember to forget The friends that proved untrue. But never forget to remember Those that have stuck by you. Always remember to forget The troubles that passed away. But never forget to remember The blessings that come each day. Anonymous
CONTENTS
Chapter 1: Introduction 9
Innate Immunity
Chapter 2: Molecular and immunological characteristics of MBL 27 Functional characterization of the lectin pathway of complement in human serum.
Molecular Immunology, 39 (2003) 655-68
29
Antibody-mediated activation of the classical pathway of
complement may compensate for mannose-binding lectin defi ciency. E urop ean Journal of Immunology, 34 (2004) 2589-98
53
Human IgA activates the complement system via the mannan-binding lectin pathway.
T h e Journal of Immunology, 167 (2001) 2861-8
73
Chapter 3: MBL and type 1 diabetes 95 Elevated Levels of Mannose Binding Lectin at Clinical
Manifestation of Type 1 Diabetes in juveniles. D iab etes, 54 (2005) 3002-6
Chapter 4: MBL and liver transplantation 109 Mannose Binding Lectin Gene Polymorphisms Confer a Major
Risk for Severe Infections After Liver Transplantation. G astroenterology, 129 (2005) 408-414
A daptive Immunity
Chapter 5: Adaptive immunity in pancreatic islet transplantation 121 HLA incompatibility and immunogenicity of human pancreatic
islet preparations cocultured with blood cells of healthy donors. H uman Immunology, 66 (2005) 494-500
Chapter 6: Summary and general discussion 135 Nederlandse samenvatting 144
Acknowledgements 149
Curriculum Vitae 151
