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Neonatal transfusion practices

Lindern, J.S. von

Citation

Lindern, J. S. von. (2011, October 27). Neonatal transfusion practices.

Retrieved from https://hdl.handle.net/1887/17989

Version: Corrected Publisher’s Version License:

Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/17989

Note: To cite this publication please use the final published version (if

applicable).

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Neonatal transfusion practices

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ISBN: 978-94-6169-118-7

Layout: Jim Navarro & Optima Grafische Communicatie, Rotterdam, The Netherlands Printing: Optima Grafische Communicatie, Rotterdam, The Netherlands

The publication of this thesis was financially supported by Willem-Alexander Kinderzie- kenhuis Leiden, Nutricia Nederland BV, Abbott BV, Sanquin Bloedvoorziening

©2011 J.S. von Lindern, Leiden, the Netherlands

Jeannette Bw 5.indd 2 26-08-11 16:50

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Neonatal transfusion practices

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op donderdag 27 oktober 2011

klokke 13.45 uur

door

Jeannette Susanne von Lindern

geboren te ‘s-Gravenhage

in 1967

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Promotie commissie

Promotor: Prof. Dr. F.J. Walther Prof. Dr. A. Brand Copromotor: Dr. E. Lopriore

Overige leden: Prof. dr. A.F. Bos, Universitair Medisch Centrum Groningen Dr. H.A.A. Brouwers, Universitair Medisch Centrum Utrecht Dr. J.J. Zwaginga

Prof. Dr. R.R.P. de Vries

Prof. Dr. H.A. Delemarre-van de Waal Dr. D. Oepkes

Jeannette Bw 5.indd 4 26-08-11 16:50

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Contents

Chapter 1 General introduction and outline of the thesis 6 Chapter 2 The use of blood products in perinatal medicine 14

Part I Umbilical cord blood

Chapter 3 Potential use of autologous umbilical cord blood red blood cells for early transfusion needs of premature infants

38

Chapter 4 A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity

54

Part II Red blood cells

Chapter 5 A comparative cohort study on transfusion practice and outcome in two Dutch tertiary neonatal centres

76

Chapter 6 Long term outcome in relationship to neonatal transfusion volume in extremely premature infants: a comparative cohort study

90

Chapter 7 Erytrocyten transfusie bij neonaten: huidige praktijk en gereviseerde landelijk richtlijn

102

Part III Platelets

Chapter 8 Thrombocytopenia in neonates and the risk of intraventricular hemorrhage

122

Chapter 9 Intraventricular hemorrhage and thrombocytopenia in very premature infants: a tale of two cities

136

Chapter 10 Trombocyten transfusie bij neonaten: huidige praktijk en gereviseerde landelijk richtlijn

148

Chapter 11 General discussion and future perspectives 164

Chapter 12 Summary 180

Chapter 13 Samenvatting 188

Dankwoord 197

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Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded

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