The handle http://hdl.handle.net/1887/54687 holds various files of this Leiden University dissertation
Author: Broekman, Winifred
Title: Mesenchymal stromal cell treatment for COPD : experimental and clinical studies
Issue Date: 2017-09-07
MESENCHYMAL STROMAL CELL TREATMENT FOR COPD
EXPERIMENTAL AND CLINICAL STUDIES
WINIFRED BROEKMAN
Cover: Tjade Bouma
Layout and printing: Gildeprint, Enschede
Copyright 2017 Winifred Broekman, Leiden, the Netherlands. All rights reserved. No part of this thesis may be reproduced or transmitted, in any form or by any means, without prior written permission of the author.
MESENCHYMAL STROMAL CELL TREATMENT FOR COPD
EXPERIMENTAL AND CLINICAL STUDIES
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 7 september 2017
klokke 13:45 uur
door
WINIFRED BROEKMAN
geboren te Amsterdam in 1982
SPONSORING: 8/7 Consultancy, Chiesi, Chipsoft
“What if I’ve forgotten the most important thing?”
HARUKI MURAKAMI – Norwegian Wood, 1987
Voor Els
TABLE OF CONTENTS
CHAPTER 1: GENERAL INTRODUCTION
CHAPTER 2: Cigarette smoke modulates repair and innate immunity following injury to airway epithelial cells
G.D. Amatngalim*, W. Broekman*, N.M. Daniel, E.P.M. van der Vlugt, A. van Schadewijk, C. Taube, P.S. Hiemstra (* contributed equally)
Plos One, 2016 Nov 9; 11 (11): e0166255
CHAPTER 3: TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor
W. Broekman, G.D. Amatngalim, Y. de Mooij-Eijk, J. Oostendorp, H. Roelofs, C. Taube, J. Stolk, P.S. Hiemstra
Respiratory Research, 2016 Jan 11; 17:3
CHAPTER 4: Functional characterization of bone marrow-derived mesenchymal stromal cells from COPD patients
W. Broekman, H. Roelofs, M.C. Zarcone, C. Taube, J. Stolk, P.S. Hiemstra
ERJ Open Research, 2016 Jun 28; 2 (2)
CHAPTER 5: A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema
J. Stolk*, W. Broekman*, T. Mauad, J.J. Zwaginga, H. Roelofs, W.E. Fibbe, J. Oostendorp, I. Bajema, M.I.M. Versteegh, C. Taube, P.S. Hiemstra (* contributed equally)
Quarterly Journal of Medicine, 2016 May 109 (5): 331-6
CHAPTER 6: Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?
W. Broekman, P.P.S.J. Khedoe, K. Schepers, H. Roelofs, J. Stolk, P.S. Hiemstra
Under review
CHAPTER 7: SUMMARY AND GENERAL CONCLUSION
ADDENDUM: Nederlandstalige samenvatting Overzicht publicaties
Curriculum vitae Dankwoord
9 21
43
65
85
103
125
147 154 155 156
