Ball, L.M.
Citation
Ball, L. M. (2010, March 4). Clinical and laboratory features of mesenchymal stromal cells in pediatric stem cell transplantation. Retrieved from
https://hdl.handle.net/1887/15035
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/15035
Clinical and Laboratory Features of
Mesenchymal Stromal Cells in Pediatric Stem
Cell Transplantation
COLOFON
Ball, Lynne Margaret 2010 ISBN: 978-90-8570-502-4
© L.M. Ball, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without the written permission of the author.
Printed by Wöhrmann Print Service, Zutphen.
The printing of this thesis was financially supported by the Willem Alexander Kinder en Jeugd Centrum, Amgen BV, Gilead Sciences BV, Genzyme Nederland and Pfizer
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Cover illustration:
Three Ages of Woman by Gustav Klimt, National Gallery of Modern Art, Rome, Italy.
By permission of Minestero per i Beni e le Attivitá Culturali.
" I have the gift of neither the spoken nor the written word, especially if I have to say something about myself or my work. Whoever wants to know something about me as an artist, the only notable thing, ought to look carefully at my pictures and try and see in them what I am and what I want to do."
- Gustav Klimt
(Baumgarten, 14 juli 1862 – Wenen, 6 februari 1918)
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Clinical and Laboratory Features
of Mesenchymal Stromal Cells in Pediatric Stem Cell Transplantation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 4 maart 2010
klokke 11.15 uur
door
Lynne Margaret Ball
geboren te Whiston, VK.,
in 1953
Promotie commissie
Promotores: Prof. Dr. R. M. Egeler Prof. Dr. W.E. Fibbe
Co-Promotor: Dr. M.J.D. van Tol
Overige Leden: Prof. F. Locatelli (University of Pavia, Italy) Prof. Dr. C.L. Mummery
Prof. Dr. R. Pieters (Erasmus University, Rotterdam)
The research described in this thesis was performed in the Departments of Pediatrics, Sub- Department Immunology, Haematology, Oncology, Bone Marrow
Transplantation and Autoimmune diseases (Prof dr. RM Egeler and Dr MJD van Tol) and Immuno-hematology and Blood Transfusion (Prof dr. W.E. Fibbe) of the Leiden University Medical Centre in collaboration with the Department of Pediatric Hematology/Oncology Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Italy, the Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institute, Huddinge University, Stockholm, Sweden and the Department of Bone Marrow Transplantation, Great Ormond Street Hospital, London, United Kingdom.
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For my husband and daughter, Dick and Hannah
Aan mijn lieve Dick en dochter Hannah
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Contents
Part 1 General introduction
Chapter 1 12
Published as
Potential role of mesenchymal stromal cells in paediatric hematopoietic stem cell transplantation.
BONE MARROW TRANSPLANTATION 2008; 42: S60–S66.
and
Immunotherapy in the context of hematopoietic stem cell transplantation; Focus on natural killer cells and mesenchymal stromal cells
PEDIATRIC CLINICS OF NORTH AMERICA. Coppes MJ, Mackall C , FryTJ (eds.) W B Saunders Company Philadelphia, USA. 2010; 57(1) in press.
Part 2 Alternative donors
Chapter 2 54
Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation.
BONE MARROW TRANSPLANTATION 2005; 35: s35-38.
Chapter 3 66
Co-transplantation of ex vivo expanded mesenchymal stem cells accelerate lymphocyte recovery and may reduce the risk of graft failure in haplo-identical hematopoietic stem cell transplantation.
BLOOD, 2007; 110: 2765-2767
Chapter 4 76
Co-infusion of ex vivo expanded, parental mesenchymal stromal cells prevents life-threatening acute GvHD, but does not reduce the risk of graft failure in pediatric patients given allogeneic
umbilical cord blood transplantation.
IN PRESS BONE MARROW TRANSPLANTATION 2010
Chapter 5 100
Multiple infusions of haploidentical mesenchymal stromal cells are not immunogenic in children undergoing myeloablative stem cell transplantation.
SUBMITTED FOR PUBLICATION
Part 3 Acute Graft versus Host Disease
Chapter 6 108
Acute GvHD: pathogenesis and classification
BONE MARROW TRANSPLANTATION 2008; 41: S58–S64
Chapter 7 128
Use of bone marrow derived expanded mesenchymal stem cells in the treatment of steroid refractory acute GvHD.
LANCET 2008 371: 1579-1586
Chapter 8 148
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft versus host disease in a child with juvenile
myelomonocytic leukemia.
LEUKEMIA 2008 22: 1256-1257.
Part 4 Viral infections
Chapter 9 156
Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T cell responses
BLOOD. 2008; 1: 112: 532-541
Part 5
Chapter 10 186
Summary and General discussion
Part 6
Chapter 11 218
Future and potential uses of MSCs in pediatric medicine
Appendices
Nederlandse Samenvatting 256
Curriculum Vitae 264
Historical footnote 276
Abbreviations 280
