Mulder, Joyce
DOI:
10.33612/diss.171825159
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Mulder, J. (2021). Activation, regulation and physiology of natural competence in Lactococcus lactis.
University of Groningen. https://doi.org/10.33612/diss.171825159
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ACTIVATION, REGULATION AND PHYSIOLOGY
OF NATURAL COMPETENCE IN
LACTOCOCCUS LACTIS
Joyce Mulder 2021
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ACTIVATION, REGULATION AND PHYSIOLOGY
OF NATURAL COMPETENCE IN
LACTOCOCCUS LACTIS
PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof.dr. C. Wijmenga en volgens het besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 18 juni 2021 om 16:15 uur
door
Joyce Mulder geboren op 19 november 1990
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Prof. dr. P. Hols Prof. dr. J. Kok Prof. dr. E.J.Smid
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“Biology is the most powerful technology ever created. DNA is software, protein are hardware, cells are factories.”
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A tree has been planted for every copy of this thesis.
© 2021 Joyce Mulder, The Netherlands. All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author. Alle rechten voorbehouden. Niets uit deze uitgave mag worden vermenigvuldigd, in enige vorm of op enige wijze, zonder voorafgaande schriftelijke toestemming van de auteur.
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TABLE OF CONTENTS
CHAPTER ONE
9
General introduction
CHAPTER TWO
49
Unleashing Natural Competence in Lactococcus lactis by Induction of the Competence Regulator ComX
CHAPTER THREE
85
High-level expression of the late competence genes in L. lactis subsp. lactis KF147 coincides with stringent response and growth stagnation
CHAPTER FOUR
119
The delicate balance between ‘’the window of competence’’ and stringent responses in Lactococcus lactis
CHAPTER FIVE
149
The quest for the environmental trigger of natural competence development in Lactococcus lactis
CHAPTER SIX
185
General discussionCHAPTER SEVEN
219
Summary Nederlandse samenvatting DankwoordAbout the author List of publications
