University of Groningen
Beyond risk-reducing salpingo-oophorectomy
Fakkert, Ingrid Elizabeth
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Publication date: 2017
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Fakkert, I. E. (2017). Beyond risk-reducing salpingo-oophorectomy: On breast cancer risk and bone health. Rijksuniversiteit Groningen.
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Beyond risk-reducing
salpingo-oophorectomy
On breast cancer risk and bone health
ISBN: 978-94-034-0077-8 (printed version) 978-94-034-0076-1 (digital version) Cover design: Ilse Schrauwers, isontwerp.nl Layout & printing: Ridderprint BV, Ridderkerk © Copyright: Ingrid E. Fakkert, 2017
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without prior permission of the author and the publisher holding the copyright of the published articles.
The research described in this thesis was supported by a Junior Scientific Masterclass MD/PhD grant of the Graduate School of Medical Sciences Groningen. Part of this research was supported with unrestricted grants provided by Amgen, Menarini, Nycomed and Willpharma. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the chapters in this thesis.
Promotores
Prof. dr. M.J.E. Mourits Prof. dr. G.H. de Bock
Copromotor
Dr. J.C. Oosterwijk
Beoordelingscommissie
Prof. dr. J.P. van den Bergh Prof. dr. ir. F.E. van Leeuwen Prof. dr. R.H. Sijmons
Paranimfen
Heleen F. Fakkert Stefan M. Wierda
Content
Chapter 1 General introduction 9
Part I: Risk-reducing salpingo-oophorectomy and breast cancer risk Chapter 2 Breast cancer screening in BRCA1 and BRCA2 mutation
carriers after risk-reducing salpingo-oophorectomy
Breast Cancer Res Treat 2011;129:157-64
31
Chapter 3 Breast cancer incidence after risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers
Cancer Prev Res (Phila) 2012;5:1291-7
45
Part II: Risk-reducing salpingo-oophorectomy and bone health Chapter 4 Bone mineral density and fractures after surgical
menopause: a systematic review and meta-analysis
BJOG 2017;124:1525-35
61
Chapter 5 Bone mineral density and fractures after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer
Eur J Cancer 2015;51:400-8
119
Chapter 6 Elevated bone turnover markers after risk-reducing salpingo-oophorectomy in women at increased risk for breast and ovarian cancer
PLoS One 2017;12:e0169673
143
Chapter 7 Summary and general discussion 165
Chapter 8 Nederlandse samenvatting 185
Appendices References 194
Dankwoord 218