University of Groningen Integrative omics to understand human immune variation Aguirre Gamboa, Raul

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University of Groningen

Integrative omics to understand human immune variation

Aguirre Gamboa, Raul

DOI:

10.33612/diss.98324185

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Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Aguirre Gamboa, R. (2019). Integrative omics to understand human immune variation. University of Groningen. https://doi.org/10.33612/diss.98324185

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Integrative omics to understand human immune variation

Propositions

1.

The Inter-individual variation in the human immune composition and response arises from a not yet completely defined, interaction between our genome and the environment we live in. This thesis

2.

Circulatory levels of B and T cell cells are differentially affected by environmental _{exposure and genetics}_{This thesis.}

3.

The production of innate cytokine signals in response to pathogen infections is tightly _{controlled by genetics.}_{This thesis.}

4.

It is possible to predict the ex vivo immune response to certain pathogen stimulations solely using genetics. However, integrating molecular, cellular and environmental factors, such as metabolomics and microbiome composition, yields a more accurate prediction. This thesis.

5.

By using gene expression levels from bulk tissues it is possible to computationally _{ascertain the proportions of known cell types within its particular tissue.}_{This thesis.}

6.

Through _{genetic variants that affect gene expression in a particular cell type.}in silico dissecting bulk gene expression into its components one can detect _{This thesis.}

7.

In the context of complex diseases, isolating and characterizing the effect of key signaling molecules in potentially causal cell subpopulations shed light into disease

aetiology. _{This thesis.}

8.

Given the complex nature of the immune system, immunogenomic cohorts aimed at exploring its inter-individual variability should collect as many phenotypes (both cellular and molecular) as possible alongside environmental information and its proxies. _This

thesis.

9.

Human immune function may converge into certain immunotypes .Such immunotypes are malleable and we might be able to tune our own immune system to further improve our health. (_{This thesis & Kaczorowski et al. PNAS, 2017)}

9.

A knowledge of the historic and philosophical background gives that kind of independence from prejudices of its generation from which most scientists are

suffering. This independence created by philosophical insight is—in my opinion—is the mark of distinction between a mere artisan or specialist and a real seeker after truth.

Albert Einstein, Letter to Robert Thornton, 1944

10.

If you cannot separate the phenotype of mental illness from creative impulses, then you cannot separate the genotype of mental illness and creative impulse.

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