Magnetic Resonance Imaging studies on
neuropsychiatric systemic lupus erythematosus
Steens, S.C.A.
Citation
Steens, S. C. A. (2006, May 31). Magnetic Resonance Imaging studies
on neuropsychiatric systemic lupus erythematosus. Retrieved from
https://hdl.handle.net/1887/4416
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of
doctoral thesis in the Institutional Repository of
the University of Leiden
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Magnetic Resonance Imaging
studies on
Magnetic Resonance Imaging
studies on
Neuropsychiatric Systemic Lupus Erythematosus
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnifi cus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op woensdag 31 mei 2006
klokke 16.15 uur
door
Stefanus Cornelis Antonius Steens geboren te Leidschendam
Promotiecommissie
Promotores: Prof. dr. M.A. van Buchem Prof. dr. T.W.J. Huizinga
Referent: Prof. dr. P.S. Tofts (Institute of Neurology, University College London, UK) Overige leden: Prof. dr. R.A.C. Roos
Dr. P.A.M. Hofman (Academisch Ziekenhuis Maastricht)
© S.C.A. Steens, Leiden, The Netherlands. All rights preserved. No parts of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without prior written permission of the author.
Printed by De Kempenaer, Oegstgeest, 2006. ISBN-10: 90-9020641-8
ISBN-13: 978-90-9020641-7
Contents
1. Introduction and aims 7
2. Imaging modalities in CNS-lupus 13
3. Sources of variation in multi-centre MTR histogram studies -
body-coil transmission eliminates inter-centre differences 25
4. Reproducibility of brain ADC histograms 47
5. The effect of corticosteroid medication on quantitative
magnetic resonance parameters of the brain 59
6. Detection of change in CNS involvement in neuropsychiatric SLE:
a magnetization transfer study 71
7. Selective gray matter damage in neuropsychiatric lupus -
a magnetization transfer imaging study 81
8. Multisequence magnetic resonance imaging study of
neuropsychiatric systemic lupus erythematosus 91
9. Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus 105
10. MRI manifestations of brain involvement in systemic lupus erythematosus:
an inventory 119
11. A neuroimaging follow-up study of a patient with juvenile
central nervous system systemic lupus erythematosus 137
12. Summary 146
Nederlandse samenvatting 150
List of publications 154
