Citation
Bleeker, E. J. W. (2011, June 1). Quantitative assessment of brain perfusion with magnetic resonance imaging. Retrieved from
https://hdl.handle.net/1887/17680
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Quantitative assessment of brain perfusion with magnetic resonance imaging
EgbErt J.W. blEEkEr 2011
arterial input function measurements, as presented in this thesis, show for both the magnitude and the phase of the Mr signal a four-leaf-clover pattern. Is this just a coincidence or are we always lucky?
Quantitative assessment of brain perfusion with magnetic resonance imaging thesis, leiden University Medical Center, with references and summary in Dutch
layout and printing: Optima grafische Communicatie, rotterdam, the Netherlands ISbN: 978-94-6169-054-8
Copyright © 2011 Egbert Jan Willem bleeker, leiden, the Netherlands. All rights reserved. No parts of this publication may be reproduced or transmitted in any form or by any means, with- out prior written permission of the author.
Quantitative assessment of brain perfusion with magnetic resonance imaging
proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit leiden, op gezag van de rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 1 juni 2011
klokke 15:00 uur door
egbert Jan Willem Bleeker geboren te Paramaribo
in 1980
Co-promotor: Dr. ir. M.J.P. van Osch
Overige leden: Prof. dr. P.r. luijten
(University Medical Center Utrecht, Utrecht, the Netherlands) Prof. dr. D.g. Norris
(Donders Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands) Dr. l. knutsson
(lund University, lund, Sweden)
Financial support for publication of this thesis was generously provided by: Philips Healthcare, Stichting bazis, Stichting Imago, J.E.Jurriaanse Stichting, guerbet Nederland bV, bayer bV, toshiba and Medrad Europe bV.
the research described in this thesis was carried out at the department of radiology (head:
prof. dr. J.l. bloem) of the leiden University Medical Center.
Aan mijn ouders
Contents
Chapter 1: general introduction 9
Chapter 2: Measurement of cerebral perfusion using MrI 13 Chapter 3: Optimal location for arterial input function measure-
ments near the middle cerebral artery in first pass perfusion MrI
49
Chapter 4: Phase-based arterial input function measurements for dynamic susceptibility contrast MrI
69
Chapter 5: A new criterion to aid manual and automatic selection of the arterial input function in dynamic susceptibility contrast MrI
91
Chapter 6: Evaluation of signal formation in local arterial input function measurements of dynamic susceptibility contrast MrI
109
Chapter 7: Discrete differences in brain perfusion between migraineurs and controls: a voxelwise comparison of interictal dynamic susceptibility contrast MrI measure- ments
123
Chapter 8: general discussion 137
Summary 151
Samenvatting 155
Publications 159
Curriculum Vitae 161
Dankwoord (Acknowledgements) 163
