DNA repair and gene targeting in plant end-joining mutants
Jia, Q.
Citation
Jia, Q. (2011, April 21). DNA repair and gene targeting in plant end-joining mutants. Retrieved from https://hdl.handle.net/1887/17582
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/17582
Note: To cite this publication please use the final published version (if applicable).
DNA Repair and Gene Targeting in Plant End-joining Mutants
Qi Jia
贾琪
To my dear Mum and Dad
献给我最亲爱的妈妈和爸爸
DNA Repair and Gene Targeting in Plant End-joining Mutants
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnifi cus prof.mr.P.F. van de Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 21 april 2011 klokke 11:15 uur
door
Qi Jia 贾琪
Geboren te Wuhu (China) in 1981
Promotiecommissie
Promotor: Prof. Dr. P.J.J. Hooykaas Co-promoter: Dr. B.S. de Pater Overige leden: Dr. E. van der Graaff
(Karl-Franzens-Universität Graz, Austria) Prof. Dr. J. Memelink
Prof. Dr. H.P. Spaink Prof. Dr. R. Verpoorte
Cover design: Kunzhi Jia & Qi Jia
Printed: Wöhrmann Print Service, Zutphen, the Netherlands ISBN: 978-90-8570-744-8
Contents
Chapter 1 7
General introduction: DNA repair and gene targeting Chapter 2 41
Characterization of Arabidopsis thaliana NHEJ mutants Chapter 3 69
Poly(ADP-ribose) polymerase facilitating back-up non-homologous end joining via micro-homologous sequences in plants Chapter 4 91
AtKu and AtParp are involved in distinct NHEJ pathways Chapter 5 111
Characterization of a plant specifi c DNA ligase AtLig6 Summary 129
Samenvatting 133
Curriculum vitae 137
Acknowledgement 139
