University of Groningen
Metallodrugs for therapy and imaging: investigation of their mechanism of action
Spreckelmeyer, Sarah
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Publication date: 2018
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Spreckelmeyer, S. (2018). Metallodrugs for therapy and imaging: investigation of their mechanism of action. University of Groningen.
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CV
Work Experiences
06/17 – today Radiopharmacist at the Charité Berlin, Nuclear Medicine Department
» Quality Management (eg. cGMP, and preparation of SOPs)
» Patient Care (Diagnostic and therapeutic tracer)
» Research and development of novel tracer (eg. Ga-68, Lu-177)
12/13 - 01/14 Head of Pharmacy „Flora-Apotheke“, Cappeln (Germany) » Maternity leave replacement: Team leader of five skilled pharmacy assistants and responsibility of emergency service and night shifts
05/13 - 10/13 Pharmacy Intern in the pharmacy „Insel-Apotheke“, Borkum (Germany)
» Daily communication with patients, support of clinics and home cares with pharmacy supplies, production of formulations
11/12 - 04/13 Pharmacy Intern in the research group of Prof. Ott, Braunschweig (Germany)
» Diploma thesis in collaboration with the University of Greifswald. Topic: Synthesis and Biological Evaluation of Rhodium-NHC-Complexes
09/11 - 10/11 Research Internship in the research group of Prof. Gasser, Zurich (Switzerland)
» Department of Inorganic Chemistry
02/11 - 03/11 Research Internship in the research group of Prof. Ott, Braunschweig (Germany)
» Department of Medicinal Pharmaceutical Chemistry 09/10 Voluntary Internship at Bayer Pharma, Berlin (Germany)
05/15 – 02/18 University of British Columbia, Vancouver (Canada) Joint PhD candidate with the University of Groningen, date of defence: 23rd February 2018
» Research group of Prof. Dr. Chris Orvig in the department of Medicinal Inorganic Chemistry: Synthesis of novel chelators for radiopharmaceuticals
» Supervision of international master and bachelor students
» Leading role in student tutorials
02/15 - 04/15 University of Copenhagen, Copenhagen (Danmark) Research stay in the research group of Prof. Stürup (Analytical Chemistry) and Prof. Lambert (Cell Biology and Physiology)
» Topic: Exploring the mechanisms of accumulation and resistance of new cytotoxic gold organometallics in comparison to cisplatin
02/14 – 02/18 University of Groningen, Groningen (The Netherlands) Joint PhD candidate with the University of British Columbia, date of defence: 23rd February 2018
» Research group of Prof. Casini in the department of Pharmacokinetics, Toxicology and Targeting: Transport mechanisms of metal based chemotherapeutics in vitro and ex vivo.
» Supervision of three master students
05/13 - 10/13 University of Greifswald, Greifswald (Germany)
Diploma Thesis, Topic: Synthesis and Biological Evaluation of Rhodium-NHC-Complexes
Degree: 1.4
10/08 - 11/13 Technical University of Braunschweig, Braunschweig (Germany)
08/01 - 06/08 Ursulaschule-Gymnasium, Osnabrück (Germany) Advanced Courses: Maths, Chemistry, Biology
Stipends & Awards
09/16 – 09/17 Centre for Blood Research Scholarship (Value approx. 5.000 EUR)
09/16 Award for best oral presentation Saskatoon, Canada (Value approx. 300 EUR)
05/15 – 02/18 Teaching Assistant at the University of British Columbia (Value approx. 160 000 EUR)
02/14 – 02/18 PhD Scholarship from University of Groningen
2011 Travel Award of the University of Braunschweig (Cost refund for IPSF congress (International Pharmaceutical Students’ Federation) Congress in Geneva, Switzerland)
09/08 – 07/10 Scholarship of the University of Braunschweig for excellent marks (Value approx. 2000 EUR)
Social Engagement
10/08 - 11/13 Elected member of the student association pharmacy 06/08 – 11/12 Life guard in Osnabrück and Braunschweig, Germany Interests and Qualifications
Qualifications Solid Computer Skills (Microsoft Office and several chemistry specific programs eg. ChemDraw, MestRenova)
FELASA C
Radiation Protection Certificate (Modul GH and OH, S4.2) GMP course certificate from AGRR
Languages English (fluent), German (native)
Hobbies Skiing, Sailing (Sailing licence for small boats), Hiking, CrossFit
Lab Experiences
Radiochemistry Knowledge of dealing with radioactivity (certificate from TRIUMF, Vancouver, Canada), Quality analysis of radiopharmaceuticals (TLC, HPLC), special interest for:
89Zr, 111In, 225Ac, 213Bi and 177Lu.
Chemistry Organic –and inorganic chemistry, analytical methods (ESI-MS, ICP-MS, IR, UV-VIS, HPLC).
Biology Cell cultures (in vitro), Precision-cut-tissue slices (ex vivo) with rat kidneys, morphology, biologic assays. Publication list
09/17 Spreckelmeyer, S.; Estrada-Ortiz, N.; Prins, G.; Van der Zee, M.; Gammelgaard, B.; Stürup, S.; De Graaf, I. A. M.; Groothuis, G.; Casini, A., On the Toxicity and Transport Mechanisms of Cisplatin in Kidney Tissues in Comparison to a Gold-based Cytotoxic Agent. Metallomics, 2017, 12, 1786-1985. IF: 3.975
07/17 Spreckelmeyer, S.; Ramogida, C.F.; Rousseau, J.; Arane, K.; Bratanovic, I.; Colpo, N.; Jermilova, U.; Dias, G. M.; Jaraquemada-Peláez, M. G.; Bénard, F.; Schaffer, P.; Orvig, C., p-NO2-Bn-H4neunpa and H4
neunpa-trastuzumab: Bifunctional Chelator for Radiopharmaceuticals and 111In Immuno-Single Photon
Emission Computed Tomography Imaging. Bionconj. Chem. 2017, 28, 2145-2159. IF: 4.818
01/16 Mari, C.; Mosberger, S.; Llorente, N.; Spreckelmeyer, S.; Gasser, G.,
Insertion of organometallic moieties into peptides and peptide nucleic acids using alternative “click” strategies. Inorg. Chem. Frontiers, 2016, 3, 397-405. IF: 4.532
12/15 Oehninger, L.; Spreckelmeyer, S.; Holenya, P.; Meier, S. M.; Can, S.; Alborzinia, H.; Schur, J.; Keppler, B.K., Wölfl, S.; Ott, I.
Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling. J. Med. Chem, 2015, 58, 9591-600. IF: 5.447
07/15 Bertrand, B.; Spreckelmeyer, S.; Bodio, E.; Cocco, F.; Picquet, M.; Richard, P.; le Gendre, P.; Cinellu, M. A.; Casini, A.
Exploring the potential of gold(III) cyclometallated compounds as cytotoxic agents: variations on the C^N theme. Dalton Trans., 2015, 44, 11911-8. IF: 4.177
09/14 Spreckelmeyer, S.; Orvig, C.; Casini, A.
Cellular Transport Mechanisms of Cytotoxic
Metallodrugs: An Overview beyond Cisplatin. Molecules.
2014. 15584-15610. IF: 2.465 Oral Presentations
10/17 Spreckelmeyer, S. H4neunpa-Trastuzumab: Evaluation of
a Novel Bifunctional Chelator for 111In
Radiopharmaceuticals and Immuno-SPECT Imaging, EANM, Vienna, Austria.
07/17 Spreckelmeyer, S. H4neunpa-Trastuzumab: Evaluation of
a Novel Bifunctional Chelator for 111In
Radiopharmaceuticals and Immuno-SPECT Imaging, ICBIC Florianopolis, Brazil.
05/17 Spreckelmeyer, S. Metallodrugs for Therapy and Imaging: Investigation of Their Mechanism of Action, guest lecture, TU Braunschweig, Germany.
09/16 Spreckelmeyer, S. Bifunctional Acyclic Chelator as Potential Therapeutic with 225Ac and 213Bi“,: Medicinal
Inorganic Chemistry Workshop, Saskatoon, Canada. 09/14 Spreckelmeyer, S. Renal Failure in Anticancer Therapy:
Falling Walls Lab competition, Groningen, The Netherlands.
as anticancer agents: investigation of their mechanisms of uptake. PhD Day, Groningen, The Netherlands.
04/14 Spreckelmeyer, S. Possible transport mechanisms for anticancer metallodrugs: new insights: COST meeting, Trieste, Italy.
Poster Presentations
08/17 Spreckelmeyer, S.; Estrada-Ortiz, N.; Van der Zee, M.; Prins, G.; Stürup, S.; De Graaf, I.A M.; Groothuis, G.; Casini, A. Cisplatin vs. Organometallic Au(III)compound: New Insights into Their Mechanisms of Action Using an Ex Vivo Model, VIenna, Austria.
05/17 Spreckelmeyer, S.; Ramogida, C.F.; Rousseau, J.; Arane, K.; Bratanovic, I.; Colpo, N.; Jermilova, U.; Dias, G. M.; Jaraquemada-Peláez, M. G.; Bénard, F.; Schaffer, P.; Orvig, C.H4neunpa-Trastuzumab: Evaluation of a Novel
Bifunctional Chelator for 111In Radiopharmaceuticals and
Immuno-SPECT Imaging, Dresden, Germany.
04/17 Spreckelmeyer, S.; Lee, F.; Pryzdial, E.; Orvig, C Overcoming the Limitations in Thrombosis Treatment: A Novel Theranostic Agent for Imaging Blood Clots, 6th
Annual Norman Bethune Symposium, Vancouver, Canada.
11/16 Spreckelmeyer, S.; Lee, F.; Pryzdial, E.; Orvig, C. Overcoming the Limitations in Thrombosis Treatment: A Novel Theranostic Agent for Imaging Blood Clots. Earl W. Davie Symposium, Vancouver, Canada.
07/16 Spreckelmeyer, S.; Arane, K.; Ramogida, C.; Orvig, C. Bifunctional Acyclic Chelator as Potential Therapeutic with 225Ac and 213Bi. Gordon conference: Metals in
06/16 Spreckelmeyer, S.; Groothuis, G.; van der Zee, M; Stürup, S.; Orvig, C; Casini, A. Toxicity and mechanism of transport of a novel organometallic Au(III) compound compared to cisplatin on rat kidney slices ex vivo. CSPS conference, Vancouver, Canada.
12/15 Spreckelmeyer, S.; Groothuis, G.; van der Zee, M; Stürup, S.; Orvig, C; Casini, A. Toxicity and mechanism of transport of a novel organometallic Au(III) compound compared to cisplatin on rat kidney slices ex vivo. Pacifichem 2015, Honolulu, USA.
12/15 Spreckelmeyer, S.; Groothuis, G.; van der Zee, M; Stürup, S.; Orvig, C; Casini, A. Toxicity and mechanism of transport of a novel organometallic Au(III) compound compared to cisplatin on rat kidney slices ex vivo. CEMM Symposium, Honolulu, USA.
08/14 Spreckelmeyer, S.; Bertrand, B.; Orvig, C.; Casini, A.; Groothuis, G. Cyclometallated gold(III) complexes as anticancer agents – investigation of their mechanisms of uptake. MCB Symposium, Groningen, The Netherlands.
08/14 Spreckelmeyer, S.; Bertrand, B.; Orvig, C.; Casini, A.; Groothuis, G. Cyclometallated gold(III) complexes as anticancer agents – investigation of their mechanisms of uptake. COST conference, Zurich, Switzerland.
