University of Groningen
Myocardial Magnetic Resonance Imaging in the characterization of Chronic Coronary
Syndromes
van Dijk, Randy
DOI:
10.33612/diss.147542794
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Dijk, R. (2020). Myocardial Magnetic Resonance Imaging in the characterization of Chronic Coronary
Syndromes. University of Groningen. https://doi.org/10.33612/diss.147542794
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Myocardial Magnetic Resonance
Imaging in the characterization of
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
The studies in this thesis were financially supported by ZonMW. ISBN: 978-94-6416-261-5
Cover: Sieben Medical Art | www.annasieben.com Lay-out: Publiss | www.publiss.nl
Myocardial Magnetic Resonance Imaging in the
characterization of Chronic Coronary Syndromes
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 23 december 2020 om 12.45 uur
door
Randy van Dijk
geboren op 11 juli 1991 te Groningen
Promotores
Prof. dr. P. van der Harst Prof. dr. M. Oudkerk
Copromotor
Dr. D. Kuijpers
Beoordelingscommissie
Prof. dr. T. Leiner Prof. dr. P. van der Meer Prof. dr. M.J. de Boer
Table of contents
Chapter 1: General introduction and outline of thesis 9
Part I – Subclinical alterations in cardiac function 19
Chapter 2: Active tobacco smoking impairs cardiac systolic function 21
Part II – Myocardial Perfusion 37
Chapter 3: Effects of caffeine on myocardial perfusion measurements: a systematic review
39 Chapter 4: Disagreement between splenic switch-off and myocardial
T1-mapping after caffeine intake
59 Chapter 5: Effects of Caffeine intake prior to stress Cardiac Magnetic
Resonance Perfusion Imaging on Regadenoson- versus Adenosine-induced hyperemia as measured by T1 mapping
77
Chapter 6: Diagnostic performance of semi-quantitative and quantitative stress MR perfusion analysis: A meta-analysis
93
Part III – Cardiac Tissue characterization 125
Chapter 7: Delta T1 as an imaging biomarker in myocardial tissue characterization
127 Chapter 8: T1 based early synthetic enhancement of myocardial
infarction accurately predicts late enhancement
143
Part IV – Future perspectives 157
Chapter 9: Replacement of invasive diagnostic coronary procedures by innovative noninvasive Imaging Technologies (REPLACE-IT): Rationale and design
159
Part V – English and Dutch summary and implications 179
Chapter 10: General discussion 181
Chapter 11: English summary 193
Chapter 12: Nederlandse samenvatting 197
Part VI – Appendices 203
Chapter 13: Dankwoord 205
Chapter 14: List of publications 209
Abbreviations and acronyms
CAD Coronary Artery Disease CCS Chronic Coronary Syndromes
COPD Chronic Obstructive Pulmonary Disease CT Computed Tomography
CMR Cardiac Magnetic Resonance FFR Fractional Flow Reserve LGE Late Gadolinium Enhancement MACE Major Adverse Cardiac Events MBF Myocardial Blood Flow MBV Myocardial Blood Volume
MOLLI Modified Look-Locker Inversion Recovery MRI Magnetic Resonance Imaging
PET Positron Emitting Tomography
SPECT Single Photon Emission Computed Tomography SSO Splenic Switch Off Sign
TI Inversion Time TruFI True Fisp
