University of Groningen
The missing piece
Winkle, Melanie
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Winkle, M. (2018). The missing piece: Long noncoding RNAs in cancer cell biology. Rijksuniversiteit
Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Melanie Winkle
The Missing Piece
The studies described in this thesis were financially supported by: Groningen University Institute for Drug Exploration (GUIDE) J.K. de Cock Foundation
Illustrations cover & p. 11, 23, 47, 71, 97, 129 Maria Wiersma
Design/layout PROEFSCHRIFTENBALIE.NL, Michel Wolf
Printed by Ipskamp Printing
© 2018 M. Winkle
All rights reserved. No parts of this book may be reproduced or transmitted in any form or by any means without prior permission of the author.
ISBN: 978-94-034-0607-7 (print)
The Missing Piece
Long noncoding RNAs in cancer cell biology
Proefschrift
Ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 23 April 2018 om 16.15 uur
door
Melanie Winkle
geboren op 22 April 1986 te Kirchheim unter Teck, Duitsland
Promotor
Prof. dr. J.H.M. van den Berg
Copromotor
Dr. J.L. KluiverBeoordelingscommissie
Prof. dr. I. Aifantis Prof. dr. M. Rots Prof. dr. J.J. SchuringaParanimfen
Mathilde de Jong Myra Langendonk Kristina Miloserdov
Contents
CHAPTER 1 11
Introduction and scope of the thesis
CHAPTER 2 23
Emerging roles for long noncoding RNAs in B-cell development and malignancy
Critical Reviews in Oncology/Hematology, 2017
CHAPTER 3 47
Long noncoding RNA expression profiling in normal B-cell subsets and Hodgkin lymphoma reveals Hodgkin and Reed-Sternberg cell-specific long noncoding RNAs
American Journal of Pathology, 2016
CHAPTER 4 71
Long Noncoding RNAs as a novel component of the Myc transcriptional network
FASEB Journal, 2015
CHAPTER 5 97
KTN1-AS1, an important downstream effector of Myc, controls B-cell lymphoma proliferation and apoptosis
Manuscript in preparation
CHAPTER 6 129
Summary, discussion and future perspectives
Nederlandse samenvatting 153
Publications 159
