University of Groningen
Towards strengthening memory immunity in the ageing population
van der Heiden, Marieke
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Publication date: 2018
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van der Heiden, M. (2018). Towards strengthening memory immunity in the ageing population: Investigating the immunological fitness of middle-aged adults. Rijksuniversiteit Groningen.
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TOWARDS STRENGTHENING
MEMORY IMMUNITY IN THE
AGEING POPULATION
Investigating the immunological
fitness of middle-aged adults
Cover Mars58 | 123RF Stockfoto
Lay-out Nikki Vermeulen | Ridderprint BV
Printing Ridderprint BV | www.ridderprint.nl
ISBN 978-94-034-0229-1 | printed book 978-94-034-0228-4 | e-book
Printing of this thesis was kindly supported by: The Dutch National Institute of Public Health and the Environment (RIVM), The University of Groningen (RUG), and the Groningen University Institute for Drug Exploration (GUIDE).
Copyright © 2017 Marieke van der Heiden
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.
Towards strengthening memory immunity in
the ageing population
Investigating the immunological fitness of middle-aged adults
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 10 januari 2018 om 11.00 uur
door
Marieke van der Heiden
geboren op 13 april 1989 te Nijmegen
Promotor
Prof. dr. A.M.H. Boots
Copromotores
Dr. A.M. Buisman Dr. G.A.M. Berbers
Beoordelingscommissie
Prof. dr. W. van Eden Prof. dr. S.M. van Ham Prof. dr. A.L.W. Huckriede
Paranimfen
Lia de Rond
Table of contents
Chapter 1 Introduction 9
Chapter 2 Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females
Sci Rep. 2016; 6: 26892
27
Chapter 3 Novel intervention in the ageing population:
a primary meningococcal vaccine inducing protective IgM responses in middle-aged adults
Front Immunol. 2017; 8: 817
57
Chapter 4 Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: role of IgM
Submitted
85
Chapter 5 Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults
Vaccine. 2017.08.056
103
Chapter 6 Age-dependent pre-vaccination immunity affects the immunogenicity of Varicella Zoster vaccination in middle-aged adults
Submitted
121
Chapter 7 An explorative biomarkers study for vaccine responsiveness after primary meningococcal vaccination in middle-aged adults
Submitted
145
Chapter 8 General discussion 169
Appendices Nederlandse samenvatting About the author
Publication list Dankwoord 187 193 194 195
