HNPCC, molecular and clinical dilemmas Wagner, A.

Hele tekst

(1)HNPCC, molecular and clinical dilemmas Wagner, A.. Citation Wagner, A. (2005, April 27). HNPCC, molecular and clinical dilemmas. Macula, Boskoop. Retrieved from https://hdl.handle.net/1887/2719 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/2719. Note: To cite this publication please use the final published version (if applicable)..

(2) 3.1.. A typical H N PC C owing to MSH6 germ line m utations; analysis of a large D utch pedigree. J Med Genet 2001:38;318-322. Clinical Studies. 97.

(3)

(4) ¥Ê. ->>,> ß5×¥ÊS¥. 2>82. @9%@-3:#-8# @-@8" % -!@.3@%" 7@4@@#- ªh·Jf :Wc/7fnw/7

(5) Rf .hJfcf 4\/J+R|v c@k/fB/7f @9%@-3*%-:#-8#@-@8" &@@--!@. /@8#:@-@" )@-@(@ 1 " >&&@@-"7@ 4@@#- ªh·Jf ´Jf/<n .ÓRYn :'/< WÓ 'f<fwf/Jn c'f|J/J· º/JfBhJ Wª/7JJ @R. vY/hÒkz..R/J·vR -)# ·fBÒ/J B|vhv/RJn×hJhÒn/nR"hÒhf·4|v+Y/·f ªh·Jfo´Jf/<no:Wc/7fnw/7

(6) Rfo ªW@ \|ocRffh|oR"nvfho .ÓRYno:'/<o WÓ 'f<fwf/Jno.hJfcfo4\/J+R|vo @ hnJo c'f|J/J·o.W.RfJÒ/nno.hJ¦f/BYJoc@k/fB/7foº/JfBhJo Wª/7JJo@R. .RffnYRJJvR× 4f@Ro @R\c.JÒ. >28 *@@.-3-'93#.9383#3@8#8-' 8@*4::

(7) @%383%%3- @-@8 8@92#..-3%@383#3@8# 8-8@0*4::%3@ @-#.8@ 2. @%#-@%3--@4>%' %8@9//

(8) @-@ - 0@8@-#."%3---3@ // @-@" #3 -3(-

(9)

(10) " !@#32@@-3(-3@#-*4::0 @#%-.-8@@9@-3' .9@@#@3 %3-%. @3%@8#8#*4::8@ 2.@@8- - 0 *@@"(@@82@-@,@-@8 *4::%#.-3###- @>%@' %8@-@#- 3% %3-0!@##"@9@-@-8@3 83#3@8#8-8@99@32@ -' 8-#.@8@@9?0??

(11) %3- @ %3-8@-%#. (@-83%9@( - 8@ +2.@ @35? 5?+

(12) 0. -3%@#8-8@@ @-%-' @3-%3- @%#@8@,33 %# --%3

(13) 07-3-#8@## 88-3%3@-.8#3 @#!@#.83%%3--23%#@- @%#@8@?+3@8@

(14) 0 /3@3!@"@%@- @33-@323 83#3@8#8-8@ .@ 6.@

(15) -@-3%@# 88-3% .@ <65.@

(16) @#.@0>9@!' 3#.@93@"(@83-%@9' @-3%83@##@-2#."83%2-3-(%%-338@%8# -#."8-9@8@9@@-8@3 @%#-@@@80 7@@#@88@3-3@ 8#-8#9@-3.9@3 -@83-2' @3@@2#%@-3 @-3.9@' 9@-3.9@83@#3--*4::3(- 3%3--9@88%%8@9 @-@0. /nfn/RJf/ µWhJ|hf Yv"RfY|

(17) Ò/hv/RJµ @

(18) f|hf. ¦Rfn×+f/vhfJRJwYRÒYRn/nRÒRfvhÒhJfß -)#. @9%@-3 3#3 ."&@@-!@./@8# :@-@"7@ 4@@#- ªW@ \| cRffh| .W.RfJÒ/nn @9%@-3 /@8#@-@8" -!@.*39# 3-- @-"7@ 4@@#- R"nvfh @9%@-3 /@8#@-@8" -!@./@8# :@-@@8"7@ 4@@#- 4\/J+R|v 7@4@@#- 3-3-3@ @@83-3 *@@.7%3" 7@4@@#- @ hnJ @9%@-3 3#3 ."@-@@ 6=" @#"7@4@@#- .hJ¦f/BYJ. N->>,> ß5×¥ÊS¥X. &&&/$>>,>/72$. f/vhfJRJwYRÒYRn/nRÒRfvhÒhJf Nkz..X/nRJR"v+BRnvRBBRJ h|vRnRBhÒRB/JhJvRJ/v/RJnYf/nYRn/J· vRhJfkz..hff/fnhfhvf/n<"Rfv+ ÒRYBJvR"h

(19) fRhnYvf|BR"BhÒ/·w JhJ/n/JÒ|/J·v|BR|fnR"v+RÒRJo JRBvf/|BonvRBh+onBhÒÒ/Jvnv/Jo+Yhw vR

(20) /Ò/hfnnvBo|fvfofJhÒYÒ/nohJ Rhf kz../nh|n

(21) ·fBÒ/JB|vhw v/RJn/J4kB/nBhv+fYh/fNccX·Jno YfRB/JhJvÒ -) RJ+fRBRnRBY» hJ -%) RJ+fRBRnRB¥Y ¥ OJhB/JRfw /vR"hnnoB|vhv/RJn+h

(22) Jnf/

(23) /J Rv+fcc·JnÒ/< - hJ - ® JvÒo·fBÒ/JB|vhv/RJn/Jv+ -)# ·JRJ+fRBRnRBYµffR·J/nhn h"f_|Jvh|nR"hvY/hÒkz..ov+hv/no JRvRBYÒ/J·/v+v+Ò/J/hÒ BnvfhB f/vf/h µSÏ Ó+/JRÒBJvR"cc·Jn/Jkz.. /nfKv

(24) v+R|ffJR"/Jnvh

(25) /Ò/vR" n/BYÒfYv/v/4kn_|JnNB/fRnhvÒw Ò/v/Jnvh

(26) /Ò/vRfcOX/Jv|BR|fn"fRB kz..Yhv/JvnRf/J·ÒoBRfv+hJ Ï8R"v+RÒRfvhÒv|BR|fnhJhvÒhnvÂµ8 R"v+JRBvf/hÒv|BR|fn"fRBkz.. Yhv/Jvn/nYÒhcO S OJnYRfh/RÒRfvhÒ hJJRBvf/hÒhJfocO/n"R|J/Jh

(27) R|v µw¥8R"v|BR|fn ¥® Ó+CfnvfYRfvnRJ -)# ·fBÒ/JB|vhw v/RJn+h/J/hvv+hvv+Ò/J/hÒY+JRvY R"v+h v"hB/Ò/nBh/ f"fRBv+ Òhnn/hÒkz..h|n

(28) -) hJ -%) B|vhv/RJnµSÏ Ó+YJvfhJR"RÒRw fvhÒhJfnBvR

(29) f|Rfo JRBvf/hÒhJfhnÒ/<ÒvRfYfnJvh BRf/BYRfvhJvÒ/J/hÒBhJ/"nvhv/RJhBRJ· "BhÒ -)# hff/fnÓ+fYRfvBhJh· R"RJnvR"RÒRfvhÒhJJRBvf/hÒhJf hYYhfvR

(30) Òh/J"hB/Ò/n/v+ -)# ·fBÒ/JB|vhv/RJnoµhfnhJRÒfRBw YhfvR®®N -) XhJ®N -%)XhfnR" h·µ hJµ¥hfnhJRÒfRBYhfvR®Ï N-) XhJ®ÊN -%)XhfnofnYv/Ò Â kRvh

(31) ÒocOhJhÒn/nR"v|BR|fn"fRB -)# B|vhv/RJhff/fnn|··nvhf|YJw vfhJR"v+cOwY+JRvYhJYf"fJw v/hÒ/Jnvh

(32) /Ò/vhvBRJRJ|ÒRv/fYhvn ÂSÏ fofYRfvv+Ò/J/hÒhJBRÒ|Òhf +hfhvf/nhv/RJR"hÒhf·kz..</Jf.

(33) ¥Ï. =.87")3992&,2-)#>$",>$2,

(34). . . . . . .

(35) . .

(36) . . . . . . . . . . .

(37) . . . . . . . . . . . . . . . . . . . . . . . . >>>>2-)#$"./972"2>7"7,7>/>,2$>"7,7>/ ,.77,7>/82".8/;2 ,7,7>/51>

(38) 7,7>/51, $2/9+7,7>2,,2&,2,/-)#$2,82

(39) >/ -)# $2,,> >/. fn|Òv/J·"fRBh"fhBn+/"vB|vhv/RJ/Jv+ -)# ·J @- Ó+YfR

(40) hJohµhfRÒ"BhÒohnf"ff vRv+4YhfvBJvR".Ò/J/hÒGJv/no. &&&/$>>,>/72$. RvvfhB

(41) +f·JhRÒR·/nv/JÏÏ¥v v+hvv/Bov+fR"+fn/3n/nvfnf /h·JRn/v+JRBvf/hÒhJfhvµoµÂo hJ»hfnR"h·"R|fv+n/nvf+hÒw RYRhf/hJhJfNJRBvfR/hJRhf/w JRBhXhvv+h·R"µÓ+YfR

(42) hJDn"hv+f /hvv+h·R"Êµ/v+R|vhJnBYvRBnR" kz..fBRv+f|JfJvh+nvfw vRB"RfÒ/RBRBhvhhvµµhJhn/J·RR +hÒv+hvÏhfnR"h· Ó+/ fJv/hÒ/h·JRn/n/Jv+/n"hB/Ò /JÒ|kz..c|vhv/RJhJhÒn/nR"v+ -%) hJ -) ·Jn

(43) z.hJ4GG: /JRJR"v+h vn/nvfnR"v+YfR

(44) hJ/ JRvn+RhJYhv+R·J/B|vhv/RJOJv+ BhJv/Bov+YfR

(45) hJÒRYJRBvf/hÒ hJfhvv+h·R"µ¥ov+"R|fv+hnR" JRBvf/hÒhJf/Jv+/nn/

(46) n+/Y nnRRJhn -)# B|vhv/RJhJhÒn/n

(47) hB hh/Òh

(48) ÒoB|vhv/RJnfJ/J·hnYf"RfB hJh"fhBn+/"vB|vhv/RJNÒÓRRJµÏ®X/J Â 3RJ®hn/Jv/C Ó+YfR

(49) hJo+f hvn/nvfnohJBRv+ff"R|JvR hffv+nhBB|vhv/RJ vv+f_|nvR"v+YfR

(50) hJo"hB/ÒBBw

(51) fnf/J"RfBh

(52) R|vv+CJ/J·nhJ f/J/vvRRJvhvv+4YhfvBJvR" .Ò/J/hÒGJv/n"Rfh/v/RJhÒ/J"RfBhv/RJ hJRfvR

(53) vnv"Rfv+YfnJR"v+ B|vhv/RJ ªfhÒnRh

(54) ÒvRÒ/J<v+"hB/ÒvR hJRv+f</Jf|Jf/Jnv/·hv/RJhvv+ 4YhfvBJvR".Ò/J/hÒGJv/nhvv+\/J J/fn/vc/hÒ.Jvf /3--#. OJvRvhÒo4kvnv/J·"Rfv+ -)# B|vhv/RJ hnYf"RfB/JÊR|vR"¥Ò//J·fÒhv/n /v+hvÒhnvhµ8f/n<R"

(55) /J·hff/fR"v+ -)# B|vhv/RJNC·XoÂBhÒnNR|vR"»¥o ®¥8XhJµ¥"BhÒnNR|vR"»ÏoÂÂ8Xr|vR" v+n¥fÒhv/nofYf/R|nÒ/h·w JRn/v+hJkz..fÒhvv|BR|fhJhÒÒ v R"v+BfvnvÓRvnv|Jh fÒhv/nfR

(56) Ò/·hvhff/fnr|vR"Âµhff/w fnhvµ8f/n<hJ®®hvµ8f/n<o®»N»8X hJN®Ê8XfvnvofnYv/ÒNvh

(57) Òn hJX ÓJR"v+h vn|

(58) 7vnfhff/fn R"v+"hB/Ò/hÒ -)# B|vhv/RJÓ+Yhv/Jv NO»XJ·hv/"Rfv+B|vhv/RJhnhµµhf RÒBhÒo/h·JRn/v+J|BfR|nv|

(59) |ÒR/Òw ÒR|nhJRBhnhvv+h·R"µ¥/J+/nÒ/J/w hÒYfnJvhv/RJhnn|··nv/R""hB/Ò/hÒ hJRBhvR|nYRÒYRn/nN@zXov+R|·+/v+h Òhh·R"RJnvoB|vhv/RJhJhÒn/nR"v+ =9 ·JhnYf"RfBÓ+/n/JRvn+R hJhÒvfhv/RJ Ó+ -)# B|vhv/RJhnRJCfB/J

(60) Rv+ |JhvR

(61) Ò/·hvhff/fn r|vR"v+®»vnv+hÒv+n|

(62) 7vn/v+h µ8f/n<"Rfv+B|vhv/RJoÂN¥Â8Xf "R|JvRhffv+ -)# B|vhv/RJßJRJR" v+Rn/v+hµ8f/n<vnvYRn/v/Nvh

(63) ÒX ÒÒÂ|Jh vB|vhv/RJhff/fnh

(64) Rv+ h·R"µhfnNCBhÒnhJ"BhÒnXf Rfv+·JfhÒÒhYvn|f/ÒÒhJ"Rf kz..oJhBÒRÒRJRnRYfRJvRvR hfnohfÒ·JhRÒR·/hÒ3hB/Jhv/RJ/v+ h·/JhÒ|ÒvfhnR|JhJ.µ

(65) ÒRRvnv/J·.

(66) ¥. ',>!)>,

(67) !->>

(68) ()>12>!>". 61">> $",,$2

(69) , >>*>,>7 -)#$". => ,2

(70)

(71) -)#$2,. >,6$2. OO.RÒRfvhÒhJf »r

(72) Ò/·hvhff/f OOOÓfhJn/v/RJhÒÒÒhf/JRBhf/·+vYÒ|BÂÂr

(73) Ò/·hvhff/f >vfhJn/v/RJhÒÒÒhf/JRBhÒ"v|fvfÂÏ OOO®ÓfhJn/v/RJhÒÒÒhf/JRBh ÂÊg OOO»J<JRJ ®kRvvnv OOO:JRBvf/hÒhf/JRBh r

(74) Ò/·hvhff/f .RÒRJhf/JRBh Â OOO¥.RÒRJhf/JRBh ÂkRvvnv OOOÊ.RÒRJhf/JRBh Ê¥g OOOÏnvfRvRBh ÂµkRvvnv O®ÓfhJn/v/RJhÒÒÒhf/JRBh|fvf µÏg O»c|Òv/YÒhJRBhvR|nYRÒYnR"v+RÒRJµ¥ OÊJRBh µg OÏJRBh ®Êg OÓ|

(75) |ÒR/ÒÒR|nhJRBh »g O¥:JRBvf/hÒ>fvhÒhf/JRBh µµg O®'fhnvhJf µkRvvnv Oµ'fhnv>RÒRJhf/JRBh ®Ïg O'fhnvhJf µkRvvnv O»:JRBvf/hÒhf/JRBh µÂg OÂ:JRBvf/hÒhf/JRBh »g O¥:JRBvfR/hJRhf/JRBhRhf µg O¥:JRBvf/hÒhf/JRBh µ¥g O¥¥:JRBvf/hÒhf/JRBh µg Ê.RÒRfvhÒhJf ¥g g/J/hvnv+YfnJR"v+ /J/hvnv+h

(76) nJR"v+. -)# B|vhv/RJ -)# B|vhv/RJ. 61"> >

(77) "

(78) 2$2,,".

(79)

(80) -">. >$">. zfvnvf/n<8`µ8µ88`µ8µ8 Ónv µµÂ -)#g ®® -)# Â kRvvnvÏÂ ÓRvhÒ µ¥®®. 62". Ê¥®Ê Ê¥Ï Ê®µ »µ Ê®¥. `Òhv/n/v+hJkz..fÒhvv|BR|fhJR

(81) Ò/·hvhff/fn. N"Rf"BhÒhff/fnXohJhfÒ|f/Jn/BJv vnv/J·hJvRÒR·4|f/J·v+CfnvnfJ/J· v+"RÒÒR/J·/h·JRnnfBh×hv|

(82) |ÒR/Òw ÒR|nhJRBh/v+nYÒhn/h/Jv+YfR3/BhÒ fv|BR"h»hfRÒBhÒßhJ/Jhn/|vhÒ hJRhf/JRBhR"v+

(83) fhnvhJhJhJRhfw /JRBhR"v+RÒRJ/Jh®ÏhfRÒ"BhÒßh nBhÒÒv|

(84) |ÒhfhJRBhhJJRBvf/hÒ+Yfw YÒhn/h/JhµhfRÒ"BhÒßhJhJhJRBh /Jh"BhÒh·®Êr"v+fBh/J/J·¥ hff/fno"R|ff|Jfv+h·R"®µhJ"R|f fh

(85) RÂhfn/v+R|vhJnBYvRBnR" v+·Jv/Yf/nYRn/v/RJRfohÏhf RÒ"BhÒ|JfJvh+nvfvRB

(86) h|n R"Ò/RBRBhvhR"v+|vf|nhvv+h·R"µµ 61">-72

(87) >"">,$$,2

(88) 27 >$7",".

(89)

(90) ,$2

(91) 2$ . Ó+"hB/Ò/JÒ|ChR

(92) Ò/·hv B|vhv/RJhff/fnov+f"BhÒnhJvRBhÒn Ó+fR"v+B+h

(93) J/h·JRn/v+h kz..fÒhvv|BR|fNvh

(94) ÒXrJBhÒ fh+v+h·R"Ê¥/v+R|v+h/J·ÒRY hJkz..fÒhvv|BR|f ªfJRvh

(95) ÒvRvfB/Jv+ -)# nvhv|nR"ChJfYhv/Jvn/Jv+/n"hB/Ò×RJ RÒRfvhÒhJfNRJnvÂX/Jh"BhÒ Yhv/JvNOOO¥X+Rn¥nJhJvnvnv J·hv/"Rfv+B|vhv/RJßRJBhÒ/v+hJ hnvfRvRBhNOOOÏXhvv+h·R"Âµov+fR" +Rn"R|f+/ÒfJ/JRvhffv+B|vhw v/RJßvR

(96) fhnvhJfYhv/JvnNO®oOo RJnvµXßhJRJYhv/Jv/v+hJfR" |J<JRJRf/·/JhfR|Jv+h·R"®NOOO»X OJvRvhÒo¥®B|vhv/RJhff/fnNÏhÒ/hJ ChXf/Jv/C/Jv+/nY/·foÂR" +RBÒRYhNYfXBhÒ/·JhJvv|BR|f Nvh

(97) ÒXr"v+hff/fn/v+hBhÒ/·JhJo "R|f+hvRYf/Bhfkz..fÒhvv|w BR|fnn/J·v+¦hYÒhJwcfBv+RoÂ8 R"v+hff/fnÒRYRÒRfvhÒhJf

(98) v+h·R"µhfnhJ¥8

(99) v+h·R"Ê hfnNBhJh·R"RJnvµµhfnofhJ·/J·"fRB ¥vRÊ¥hfnXr"v+"BhÒhff/fnoµ8 ÒRYJRBvf/hÒhJf

(100) v+h·R"Ê hJhÒÒR"v+Bf/h·JRnh

(101) Rv+h·R" µhfnÓ+fhff/fn+hhYhY/ÒÒhfvfhJn/w v/RJhÒÒÒhf/JRBhR"v+|f/JhfvfhvN8 R"v+hff/fnX /83@##@-2#./

(102) - %%-338@%8#*:

(103) -#.@ ªYf"RfBcOhJhÒn/nhJRf/BB|JRw +/nvR+B/nvf/v+hJv/

(104) R/nh·h/Jnvc\o cohJc» RJv|BR|fnhBYÒn f/"fRBn|

(105) 7vnß/J"R|fhnnovR /JYJJvv|BR|fnhBYÒnfvnv Nvh

(106) Ò¥X n/J·v+Bhf<fnfRBBJ

(107) 'RÒhJ >" o» cOhJhÒn/nn+Rhf/h

(108) ÒYhvvfJn Nvh

(109) Ò¥XRfohÒÒv|BR|fnhBYÒnf/ "fRBv+ -)# hff/fn/nYÒh/Jnvh

(110) /Ò/vR" hvÒhnvRJBRJRJ|ÒRv/Bhf<f+JhJ 3vJnvR"Bhf<fno/JÒ|/J·'Ó®ohn |n OBB|JR+/nvR+B/hÒNO.XhJhÒn/nR"v+ c»YfRv/J/Jv|BR|fnv/RJnn+RJR 3Yfnn/RJ/JhJR"v+nhBYÒnvnvo/v+. >7>>" >

(111). 1>7 /. ///4/. /#/. Ó|BR|fvY ..z:.'::r: c/fRnhvÒÒ/vnvhv|n\kÓ\\\ cRJRJ|ÒRv/Bhf<fn 'Óµ` gggkÓgggggg 'Ó»` kÓgkÓ ggggggggg 'Ó® gggkÓgggggggkÓggg 4/J|ÒRv/Bhf<fn 4¥` gkÓkÓkÓ 4µ¥®»` gkÓgg 4Âµ` gkÓkÓ gg OBB|JR+/nvR+B/nvf c\ kÓkÓgggggkÓggggggggggggg c kÓkÓggggggkÓgggggggggg c» kÓkÓgkÓgkÓ. /. / #/ 0/</. . » `Bhf<fnfRBBJ

(112) k.O"RfcOhJhÒn/n gJnvh

(113) Òvh

(114) ÒkÓJRvvnvJRvRJÒ|n/cO+/·+hRf/J·vRk.OfRBBJhw » » cOnvh

(115) ÒhRf/J·vRk.OfRBBJhv/RJn .RÒRJv|BR|f|f/Jhfvfhvv|BR|f v/RJn» \cOÒRhRf/J·vRk.OfRBBJhv/RJn :JRBvf/hÒv|BR|frRhf/hJv|BR|ffvhÒv|BR|fzYRÒY'

(116) fhnvv|BR|f OBB|JR+/nvR+B/nvf×gggnvfRJ·nvh/J/J·oggBRfhvnvh/J/J·ogh<nvh/J/J·oJRnvh/J/J·. &&&/$>>,>/72$.

(117) ¥. =.87")3992&,2-)#>$",>$2,

(118). v+3Yv/RJR"OOO¥hJO»zhv/JvOOO¥ R|ÒJRv

(119) vnv"Rf/v+fv+YfnJR" v+·fBÒ/JB|vhv/RJRf"RfcOohJ/nÒ/<Ò vRfYfnJvhY+JRRYo/J/R"v+Òhv h·R"RJnvNRÒRJhf/JRBhhvÂhfnX hJv+"h/Ò|fvRvvv+ -)# B|vhv/RJ /J+f¥nJhJvnªfh

(120) ÒvR Yf"RfBcOhJhÒn/n/Jhn/J·ÒhJRBh "fRBYhv/JvO»v+hv/JRv/nYÒh /Jnvh

(121) /Ò/v"RfhJR"v+vnvBhf<fn c\hJcO.hJhÒn/nhnYRn/v/ /JhÒÒnhBYÒn/v+v+3Yv/RJR"v+ fvhÒhf/JRBh"fRBO¥oJ·hv/"Rf c 83GJv/+vfR·J/vhJhf/h

(122) ÒY+JRvY/ 3Yfnn/RJfYfnJvBh7RfRBYÒ/hv/RJn/J v+/h·JRn/nhJÒ/J/hÒBhJh·BJvR" kz..oRJR"v+BRnvRBBRJ/J+f/v Yf/nYRn/v/RJnvRB|Òv/Rf·hJv|BRf/·Jn/n Òv+R|·+v++hÒÒBhf<R"v+/nRJ/v/RJ/nfYw fnJv

(123) RÒRfvhÒÒn/RJnoh

(124) fRhfhJ·R" hJfvYno/JÒ|/J·v|BR|fnR"v+Jw RBvf/|BonvRBh+onBhÒÒ/Jvnv/Jo+YhvRw

(125) /Ò/hfnnvBohJ|fvfohfnvh

(126) Ò/n+Ò/J/w hÒ3Yfnn/RJnR"kz..Ó+hnvBh7Rf/v R"kz..hnnhf<JRJvRfn|Òv"fRB ·fBÒ/JB|vhv/RJn/Jv+4kB/nBhv+ fYh/f·Jn -) hJ -%)Â OJv+n</Jw fno+/·+YJvfhJhJhfÒRJnvR" RÒRfvhÒhJJRBvf/hÒhJfhfv+ Bh7RfÒ/J/hÒ"hv|fnÓ+nvR"/h·JRnv/ f/vf/hoBnvfhBf/vf/hOhJOOonvh

(127) w Ò/n+

(128) v+OJvfJhv/RJhÒ.RÒÒh

(129) Rfhv/ GfR|YRJkz.. ÊÏ ÒÒnfv+Y|fYRn R"nÒv/J·"hB/Ò/n/v+h+/·+Ò/<Ò/+RRR" hff/J· -) hJ -%) B|vhv/RJnÂ cRf fJvÒohvY/hÒkz.."hB/Ò/nov+hv/noJRv RBYÒ/J·/v+v+BnvfhBf/vf/hN.O hJOOXv+R|·+ÒhfÒn|··nv/R"hkz..w Ò/</J+f/vRJ/v/RJo+h

(130) JfYRfvvR

(131) h|n

(132) ·fBÒ/JB|vhv/RJn/Jhv+/f cc·JoJhBÒ -)#ÂSÏ zfÒ/B/Jhf Y+JRvY/hJhÒn/nR"v+n"hB/Ò/nn+Rh f|R|ffJR"RÒRfvhÒhJfhJh YfhÒJR"JRBvf/hÒv|BR|fn fo+hYfnJvhvh/ÒhJhÒn/n R"hJ3vJ4|v+kz..Y/·f fn|Òv/J·"fRBhJ/Jhv/hv/J··fBÒ/JB|vhw v/RJR"v+ -)# ·J Ó+3Yfnn/RJR"v+ -)# B|vhv/RJ/J v+/n"hB/Òn|··nvnhf|YJvfhJhJh Òhh·R"RJnv"RfRÒRfvhÒhJf n/J·v+¦hYÒhJwcfBv+RoÂ8R"v+ hff/fnÒRYRÒRfvhÒhJf

(133) v+h· R"µhfnhJ¥8

(134) v+h·R"Êhfn Ó+/n/nn/·J/ChJvÒf|NYXRBw YhfvR Òhnn/hÒkz..h|n

(135) -) hJ -%) Naµµ8

(136) h·µhJÊ8

(137) h· µ ÊX B/vvÒov+nhÒ|Òhv/RJnhf

(138) hn RJhÒ/B/vJ|B

(139) fR"hnnhJBh fYfnJvhJRfnv/Bhv

(140) h|nJRvhÒÒ +hÒv+Ò/·/

(141) ÒfÒhv/nfvnv"Rfv+ -)# B|vhv/RJcRfRfov+nÒv/RJ

(142) /hn /JvfR|+Jnv|/J·h"hB/Ò/v+n|+h nvf/</J·Ò/J/hÒ+/nvRfBhhÒnRÒhvRhJ Rfnv/Bhv/RJR"v+YJvfhJÓ+BhJ h·R"RJnvR"v+RÒRfvhÒhf/JRBhn/Jv+/n "hB/Ò/nµµhfnÓ+/n/nÒh+J. &&&/$>>,>/72$. RBYhf/v+kz.."hB/Ò/nh|n

(143) -) N®®hfnXhJ -%) N®hfnXB|vhw v/RJnµ Ó+/nÒhh·R"RJnvBhhÒnR

(144) /hn v+nv/BhvYJvfhJkRvh

(145) Òov+R|J·w nv/h·JRnhnhnhv¥hfno/BYÒ/J· v+hvYf/R/nfJ/J·fRBBJhv/RJn n+R|ÒJRv/ f"fRBv+Rnnvh

(146) Ò/n+"Rf Òhnn/hÒkz..|Jv/ÒBRfhvhhfhh/Òh

(147) Ò OJv+/n"hB/ÒoJRBvf/hÒhJf/nv+BRnv RBBRJv|BR|fvYNn/3R|vR"¥BhÒ/·JhJv v|BR|fnXhBRJ·"BhÒhff/fnÒÒv+ JRBvf/hÒhJfnf/h·JRnh

(148) Rv+ h·R"µhJv+/fBhJh·R"RJnvhnµµ hfnov+hv/noCvRhfnÒhvf+J RBYhf/v+ Òhnn/hÒkz..h|n

(149) B|vhv/RJn/J -%) hJ -) Â JRv+fnvf/</J·Ò/J/hÒY+JRvY/Jv+/n "hB/Ò/nv+YhY/ÒÒhfvfhJn/v/RJhÒÒÒhf/w JRBhR"v+|fvfhJfJhÒYÒ/nR

(150) nf/J v+ffÒhv/nN8R"v+hff/fnXkRvh

(151) Òo v+Ò/"v/B|B|Òhv/f/n<R"v+/nv|BR|fvY /J -%) Rf -) B|vhv/RJhff/fn/nRJÒ »8 ÂSÏ nYf/R|nÒfYRfv

(152) |nhJRv+fno v+cOY+JRvYh|n

(153) ÒRnnR" -)# "|Jv/RJ/nf|+JRBYhf/v+ -%) hJ -) ohJ/ fn/J/vnYfRB/w JhJhvBRJRJ|ÒRv/f|JnÓ+/n/n/J h·fBJv/v+Yf/R|nnv|/nRJhnvhJ BR|nBRÒnnvBn ¥ @fRBv+/nYR/JvR" /ov+nvR"Bhf<fnYf/R|nÒfRBw BJ

(154) k.O"RfcOhJhÒn/n » BhJRv

(155) n|/vh

(156) Ò"Rf -)# B|vhv/RJhff/fnhJ n+R|Ò

(157) RBYÒBJv/v+hnvR" BRJRJ|ÒRv/Bhf<fnOJn/3R"v+hnn fYRfv+fNOOO®oO®oO¥:oOµ.o OÂohJO¥XNvh

(158) Ò¥Xo/Jnvh

(159) /Ò/vhn R

(160) nfhvRJÒRJRfvRBRJRJ|ÒRv/ fYhvnNRJR"+/+hnJRv/JÒ|/Jv+ k.OYhJÒXÒh/J·vRhJcOwÒRRfnvh

(161) Ò Òhnn/Chv/RJOJCR"v+nhnnoO.hn Yf"RfBhJ/J/hvv+ÒRnnR"c»/J v+v|BR|fÓ+f"RfofRBBJO. hJhÒn/n/JcOw\hJcv|BR|fn"fRB hnn/v+h"hB/Ò+/nvRfn|··nv/R" kz.. ªhÒnRn+Rv+"hn/

(162) /Ò/vR"v+O. hYYfRh+JRvRJÒRJRÒRfvhÒv|BR|fn

(163) |v hÒnR/Jhf/JRBhR"v+JRBvf/|Bo|f/Jhf vfhvohJ

(164) fhnvÓ+ÒhvvfCJ/J·/nfÒhJv "Rfv+/JÒ|n/RJR"

(165) fhnvhJf/Jv+ kz..v|BR|fnYvf|B×

(166) fhnvv|BR|f nhBYÒn"fRBOµn+R

(167) Rv+cOw+/·+hJ hJ·hv/O.nvh/J/J·YhvvfJ/JhRfhJ /v+v+YfnJR"v+ -)# ·fBÒ/J B|vhv/RJ/Jv+/nYfnRJÓRh/v/RJhÒ Yf/BJRYh|nhÒ

(168) fhnvhJfhnnf"R|J /Jv+YfnJvnv|NO®hJOX RfohnJRBhvf/hÒhnhh/Òh

(169) Ò"fRB v+nYhv/JvnoR|ÒJRvnvh

(170) Ò/n+v+/f -)# B|vhv/RJhff/fnvhv|n O.hJhÒn/nhnhÒnR+ÒY"|Ò/Jv+ hnnnnBJvR"v+Ò/<ÒY+JRRYnvhv|nfÒhw v/vROOO¥nhÒ/B/vhBR|JvR"hRÒRfw vhÒhf/JRBhhnhh/Òh

(171) Ò"fRBv+/nh Yhv/JvoÒ/B/vR|fhJhÒn/nvRO.hJ "R|JJRfBhÒc»YfRv/J3Yfnn/RJ cRfRfohÒÒ+fnJhJvnvnvJ·hv/ "Rfv+B|vhv/RJJRv+fhYhv/Jv"fRB.

(172) ¥. ',>!)>,

(173) !->>

(174) ()>12>!>". v+/n"hB/ÒoOOOÏohn/h·JRn/v+hnvfRw vRBhhvv+h·R"Âµ·h/JoJRhf+/hÒBhvw f/hÒhnhh/Òh

(175) Ò"fRBv+/nYhv/JvRfo v+Òhh·R"RJnvhJv+"hvv+hvv+f R"+/n+/ÒfJvnvJ·hv/"Rfv+B|vhv/RJo RJRvhÒÒR|nvRfhhJRJÒ|n/RJRJv+ fÒhv/RJn+/Y

(176) vJv+YfnJR"v+

(177) fh/J v|BR|fhJv+ -)# "v zhv/JvO»YfnJv/v+hÒ/J/hÒY+JRw ® vYBRfn|··nv/R"hvvJ|hvYRÒYRn/n fhv+fv+hJkz..Rf/J·ÒocOhJhÒw n/nR"v+RÒRJ/YRÒYnhnJ·hv/NcX hJJRfBhÒc»3Yfnn/RJhn"R|J

(178) O.@h/Ò|fvRvvv+ -)# B|vhv/RJ/J v+/nYhv/JvRJCfBv+hvv+hvvJ|hv YRÒYRn/n/nÒ/<ÒvRfn|Òv"fRBhJ|JÒ/J< ·Jv/Yf/nYRn/v/RJ 0 OJRJÒ|n/RJov+Ò/J/hÒ"hv|fnhnnR/hv /v+ -)# ·fBÒ/JB|vhv/RJnnvfRJ·Òn|Yw YRfvv+/JÒ|n/RJR"JRBvf/hÒhJfhJ vfhJn/v/RJhÒÒÒhJfR"v+|fvfhJfJhÒ YÒ/n/Jv+/h·JRnv/f/vf/h"Rfkz../J v+JBnvfhB.f/vf/hN.OOXhn"RfB|w Òhv

(179) v+O.Gwkz.. Ï OJh/v/RJo YfRYRnvRYf"RfBcO/JRB

(180) /Jhv/RJ/v+ O./JhÒÒBnvfhBJ·hv/"hB/Ò/n/v+h Ò|nvf/J·R"JRBvf/hÒRf|f/JhfvfhvhJw fnÓ+RB

(181) /JcOhJO.hJhÒn/n/ÒÒ /fvn|

(182) n_|JvB|vhv/RJhJhÒn/n"Rf -)# ªv+hJ<4fWWzcz /vfno·JhRÒR·/nvo"Rff"ff/J·v+ "hB/ÒvRv+4YhfvBJvR".Ò/J/hÒGJv/noRvvfhB \J+ÓoÒh.+hYÒÒGJv/n|nYv/

(183) /Ò/vvRJRJw YRÒYRn/nRÒRfvhÒhJf ->>,> ÏÏÏß$×ÊwÊ @/n+Òo\nRc¦ohRco.RYÒhJkGoWJ</Jnko Ghf

(184) fWo¦hJco¦RÒRJfÓ++|BhJB|vhvRf·J +RBRÒR·chJ/vnhnnR/hv/RJ/v++f/vhf JRJYRÒYRn/nRÒRJhJf 9>"" ÏÏ¥ß1×Âw¥Ê ¥'fRJJf.:o'h<fcocRff/nRJzÓoªhffJGoB/v+ \Go\nRc¦o¦hJco:hfh

(185) /JR.o\/Y"RfWo \/J

(186) ÒRBoÓhJJf·fzo'RÒÒh·WoGR/Joªhf 4.okRfJn<7 Òco@/n+Òo¦RÒRJfo\/n<hc c|vhv/RJ/Jv+4kB/nBhv+fYh/f·J+RBRÒR·| +c\/nhnnR/hv/v++f/vhfJRJwYRÒYRn/nRÒRJ hJf 3> ÏÏ®ß$5×µÊw» ®k/RÒh/nk.ozhYhRYR|ÒRnko\/|'oª/´@o.hfvf ¦.o|

(187) JcoRnJ.ohnÒv/Jªo@Ò/n+BhJJ 4o@fhnf.cohBnc4oJvfW.ochÒRÒBG4o hB/ÒvRJozvfnJGco.+hYÒÒÒhoR·Ònv/J 'o¦/JÒf¦ªc|vhv/RJnR"vRzc+RBRÒR·|n/J +f/vhfJRJYRÒYRn/nRÒRJhJf 3> ÏÏ®ß1×Âµw Ê µ</hBhóhvRo´hBhhÓokh·hnh</oÓn|+/ho

(188) o´|hnh´GfBwÒ/JB|vhv/RJR"v++c»GÓ'z ·J/JhJhvY/hÒ+f/vhfJRJYRÒYRn/nRÒRfvhÒhJw f</Jf 9,7> >

(189) ÏÏÂß1×¥Ïw¥ »c/h</co¦RJ/n+/coÓhJh<h¦o¦/<|+/w´hJRn+/vho c|fhR<hco´hn|JRcoO·hf/Óo¦R/<co.+/

(190) hcocRf/ ÓGfBÒ/JB|vhv/RJR"c»hnv+h|nR"+f/vhf JRJYRÒYRn/nRÒRfvhÒhJf 3>,> ÏÏÂß1×Âw Âª/7JJWo\|ªohnJohJf¦Ò/"vocRÒÒfzo vRfBRf<Joc/7fnw/7

(191) Rfo\/J+R|v4ocJ<R@o RnnJocRnÒ/JGoÓRYn.o'fR<fwf/Jnoª|ó R"nvfho/7BRJno.RfJÒ/nn.ocRffh|o@R @hB/Ò/hÒJRBvf/hÒhJf/J"BhÒhff/fnR"c» ·fBÒ/JB|vhv/RJn 3>,> ÏÏÏß ×®w® Êª|ó'fJncWocJn/J<Go¦BY/J·h.o/7BRJn ohJ4fºGoRÒÒBho¦Ò/

(192) |<fWo'|n .oR"nvfhcnnR/hv/RJR"+f/vhfJRJYRÒYRn/n. &&&/$>>,>/72$. RÒRfvhÒhJfwfÒhvv|BRfn/nYÒh/J·ÒRB/fRnhvÒw Ò/v/Jnvh

(193) /Ò/v/v+c»·fBÒ/JB|vhv/RJn =$)$ >,> ÏÏÏß$×ÏwÊ Ï¦RÒRJf4oÓvÒÒW4o+B/vnW\o¦hJc@oG|Yvh4o ª·fWoªh+Ò

(194) f·o@R3:ozÒ4oº/R·hnoGhf

(195) fW:o J·hÒoJvRJw.|Òfo\/@zGfBwÒ/JBn+» B|vhv/RJn/JRÒRfvhÒhJf"hB/Ò/n 9,7> >

(196) ÏÏÏß<×µ»ÊwÂ® @|7/hfhÓovRÒ<fWcoªhvhJh

(197) Óohn+/o\RJ·Rzo :n+ÒBhJWo'RR<fo\J+ÓoWhnnWoGfJWo¦/B oWJWoR·Ònv/J'ohB/ÒvRJ|B|ÒhvÒRJhÒ ·Jv/hÒvfhv/RJn/J"hB/Ò/hÒhJnYRfh/RÒRfvhÒhf/w JRBhn/v+/nYfh/Jnvh

(198) /Ò/v/JB/fRnhvÒÒ/vnw _|Jn =$ 2" ÏÏÊß×»¥wÂÊ O+/<hhó\BRJWoªhJ·o@fhJ<Ò/J'oªhvnRJzo ¦Jv/Wo'vfh.o\J+Óc/fRnhvÒÒ/v/Jnvh

(199) /Òw /vhJ3Yfnn/RJR"c\hJc/JJRfBhÒhJ BhÒ/·JhJvJRBvf/hÒhJRhf/hJY/v+Ò/|B/J+f/w vhfJRJYRÒYRn/nRÒRfvhÒhJf"hB/ÒBB

(200) fn 9,( 7>>,>9.2>,> ÏÏÏß ×wÊ \|ªWo4/fnnJWohnJ@oª/7JJWÓo¦JvfGGo c/7fnw/7

(201) Rfo'fR<fwf/JnovRfBRf<Jo cRÒÒfzocJ<R@o.RfJÒ/nn.WocRffh|zf/v/RJ R"hB/nBhv+fYh/f·J"v

(202) B/fRnhvÒÒ/v/Jnvh

(203) /Òw /vhJ/BB|JR+/nvR+B/hÒhJhÒn/n/JJRBvf/hÒ v|BR|fn"fRBkz..Yhv/Jvn 2" ß< ×¥Êw ¥µ ¥ORJRóz/JhRcochÒ<+RnhJo+/

(204) hvh4ozf|+R c

(205) /_|/vR|nnRBhv/B|vhv/RJn/Jn/BYÒfYhv n_|JnfhÒhJB+hJ/nB"RfRÒRJ/hf/JR·Jw n/n 3> ÏÏ¥ß$×µµÊw» ®ÒÒhJo'RffnJw4hÒ\ozÒvRBh</zo<vRJco ¦f/nvJnJG'oknÒhJWcoÒh.+hYÒÒo\Rv+ c/fRnhvÒÒ/v/Jnvh

(206) /Ò/v/Jf/hÒhJJRBvf/hÒhf/w JRBhn ,9,7> ÏÏÂß1?×®ÏÏwµ µhnJ@oª/7JJWÓocJ<R@o¦Ò/

(207) |<fWoÓhhÒ'Go Gf/RJGokh·J·hnv@coc/7fnw/7

(208) Rf:o'fw vhf/R\ohfnR\o'/n·hhfc\ocR+fWo@Ro¦+hJ zc.hJff/n</J"hB/Ò/n/v++f/vhfJRJYRÒYRn/n RÒRfvhÒhJf/h·JRn

(209) B|vhv/RJhJhÒn/nNY|

(210) w Ò/n+ffhv|BhYYhfn/J

(211) 2>,>2"2. ÏÏ»ß×®X

(212) 2>,>2"2. ÏÏ»ß?×wÂ »'RÒhJ.oÓ+/

(213) Rh|kohB/ÒvRJo/fhJn<4o :n+ÒBhJWo'|fvªocÒvfWoRf/·|w'/·hnco @RohJhJ/Gkof/hnvhhkhv/RJhÒ.hJf OJnv/v|vªRf<n+RYRJc/fRnhvÒÒ/vOJnvh

(214) /Ò/v"RfhJf vv/RJhJ"hB/Ò/hÒYf/nYRn/v/RJ×ÒRYBJvR" /JvfJhv/RJhÒf/vf/h"Rfv+vfB/Jhv/RJR"B/fRnhvÒÒ/v /Jnvh

(215) /Ò/v/JRÒRfvhÒhJf 9,7> >

(216) ÏÏÊß5×µ®Êw µÂ Âª/7JJWÓohnJ@o¦+hJzcoº/JfBhJohJf ¦Ò/"voc|ÒfoÓRYn.ocRÒÒfzo@R.Ò/J/hÒ CJ/J·n/v+/BYÒ/hv/RJn"Rf·Jv/vnv/J·/J"hB/Ò/n /v+Ò|nvf/J·R"RÒRfvhÒhJf 3,"-> ÏÏÊß<×µwÊ ÊhnJ@oc<Ò/JWzo¦+hJzco\J+ÓÓ+ OJvfJhv/RJhÒ.RÒÒh

(217) Rfhv/GfR|YRJf/vhfkRJw zRÒYRn/n.RÒRfvhÒ.hJfNO.Gwkz..X

(218) 92"2, >7$ ÏÏß×®®wµ ÏhnJ@oªhvnRJzoc<Ò/JWzo\J+ÓkÒ/J/hÒ f/vf/h"Rf+f/vhfJRJYRÒYRn/nRÒRfvhÒhJf Nkz..o\J+nJfRBXYfRYRn

(219) v+OJvfJhv/RJhÒ .RÒÒh

(220) Rfhv/·fR|YRJkz..

(221) 2>,>2"2. ÏÏÏß $×®µ¥w» ªhvnRJzohnJ@oc<Ò/JWzoWhf/JJo\J+Ó Ó+f/n<R"JRBvf/hÒhJf/J+f/vhfJRJYRÒYRn/n RÒRfvhÒhJf =$-> ÏÏ®ß<$×µ»w /7BRJno¦/BJ\oª/v7nWohnJ@f/Jhf vfhvhJfhJ+f/vhfJRJYRÒYRn/nRÒRfvhÒhJf× f/n<nhJnfJ/J·RYv/RJn 2" ÏÏÊß$?×®»»wÂ ÒhJ/:Ó+h+hfRBnf/n/hcn+hJcn+» YfRv/Jn"RfBhRBYÒ3v+hvnY/ChÒÒ

(222) /JnvR|YÒ3 RÒ/·RJ|ÒRv/nRJvh/J/J·B/nBhv+4k

(223) hnYh/fn -2"9>""52" ÏÏ»ß$×µ»®wµ ¥:ÒBhJJªo´hJ·¦oBhfofWo\h|¦o@hJ¦o \/v<ªo.R+Jz:o¦hJc@o\/Y"RfWo´|ko.fR|n G@ozRÒÒhfWªo¦|J<ÒÓo\/Y</Jco¦RÒRJfo¦|+fw ÒhYhv/c|vhv/RJ/Jv+B/nBhv+fYh/f·Jcn+» h|nnhJfn|nYv/

(224) /Ò/v 9>"" ÏÏÂß<×®»ÂwÂÂ ®\YYfvco'|fvo|·+nWzohBR/vªokh<hB|fhó ªRRhfoGhfJf:o\hÒR|ÒWcoª+/vGJv/ hJhÒn/nR"hJ/J+f/vYf/nYRn/v/RJvRRÒRJhJf/Jh "hB/Ò/v+hhf/h

(225) ÒJ|B

(226) fR"hJRBhvR|nYRÒYn 3 ,"-> ÏÏß ×Ï®wÊ.

(227)

(228)

No results found