Citation
Engelsma, D. H. (2008, October 16). Nuclear export signals: small domains with large impact. Retrieved from https://hdl.handle.net/1887/13258
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13258
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Nuclear Export Signals:
Small Domains with Large Impact
Dieuwke Engelsma
Nuclear Export Signals:
Small Domains with Large Impact
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 16 oktober 2008 klokke 13.45 uur
door
Dieuwke Hermine Engelsma geboren te Terneuzen
in 1979
Referent: Dr. N. Divecha
Patterson Institute for Cancer Research
Overige leden: Prof. dr. E.J.H.J. Wiertz Prof. dr. T.N.M. Schumacher Prof. dr. P.J. Peters
Nederlands Kanker Instituut, Amsterdam
Prof. dr. T.K. Sixma
Nederlands Kanker Instituut, Amsterdam Prof. dr. J.P. Medema
Universitair Medisch Centrum Utrecht
The work described in this thesis was performed at the Division of Tumor Biol- ogy of the Netherlands Cancer Institute, Amsterdam, The Netherlands.
ISBN 978-90-810762-5-8
Contents
Summary
Chapter 1 General introduction
Chapter 2 Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358 Chapter 3 A supraphysiological nuclear export is required for parvoviral nuclear export
Chapter 4 Parvoviral NS2 inhibits mRNA export from the nucleus Chapter 5 Homodimerization antagonizes nuclear export of survivin Chapter 6 Nup214-Nup88 nucleoporin subcomplex is required for
CRM1-mediated 60 S preribosomal nuclear export
Chapter 7 General discussion
Nederlandse samenvatting voor niet-ingewijden Curriculum Vitae
List of publications Abbreviations
Page
7 9 31
47
63 71 83
97 109 111 111 113
