University of Groningen
Aneuploidy in the human brain and cancer van den Bos, Hilda
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Publication date: 2017
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van den Bos, H. (2017). Aneuploidy in the human brain and cancer: Studying heterogeneity using single-cell sequencing. University of Groningen.
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Stellingen behorende bij het proefschrift
Aneuploidy in the human brain and cancer
Studying heterogeneity using single-cell sequencing
1. Sequencing the DNA of single cells without pre-amplification is a solid method to identify aneuploidy in individual cells. (This thesis)
2. Sometimes the whole is less than the sum of its parts; analyzing individual cells of a tissue can give more information than the tissue as a whole. (This thesis)
3. Aneuploidy is unlikely to play a major role in the development or progression of Alzheimer’s disease. (This thesis)
4. Tumor cell heterogeneity is important in the development and progression of cancer, and its detection using single cell sequencing will become a key diagnostic tool and play an important role in developing personalized treatment. (this thesis)
5. Development of both ‘wet lab’ protocols as well as bioinformatical tools is essential to get the most information from the available samples and data.
6. "The hardest problems of pure and applied science can only be solved by the open collaboration of the world-wide scientific community. [ ] Scientists, wherever they may be, should be listened to in both government and industry when they report their findings. " - Kenneth G. Wilson
7. "The amount of energy needed to refute bullshit is an order of magnitude bigger than to produce it." - Bullshit Asymmetry Principle AKA Brandolini's law
8. "The more I learn, the more I realize how much I don't know". - Albert Einstein
