University of Groningen
Developing e-health applications to promote a patient-centered approach to medically
unexplained symptoms
van Gils, Anne
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Gils, A. (2019). Developing e-health applications to promote a patient-centered approach to medically
unexplained symptoms. Rijksuniversiteit Groningen.
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Developing e-health applications to
promote a patient-centered approach
to medically unexplained symptoms
© 2019, Anne van Gils
Cover design: Kim Hunnersen – www.helemaalkim.com Lay-out: Anne van Gils, ProefschriftMaken
Printing: ProefschriftMaken – www.proefschriftmaken.nl
Publication of this dissertation was financially supported by the University Medical Center Groningen, the University of Groningen, and Research Institute SHARE.
ISBN: 978-94-034-1661-8 (printed version) ISBN: 978-94-034-1660-1 (digital version)
Developing e-health applications to promote a
patient-centered approach to medically unexplained symptoms
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 3 juli 2019 om 16.15 uur
door
Anne van Gils
geboren op 7 december 1986 te Rotterdam
© 2019, Anne van Gils
Cover design: Kim Hunnersen – www.helemaalkim.com Lay-out: Anne van Gils, ProefschriftMaken
Printing: ProefschriftMaken – www.proefschriftmaken.nl
Publication of this dissertation was financially supported by the University Medical Center Groningen, the University of Groningen, and Research Institute SHARE.
ISBN: 978-94-034-1661-8 (printed version) ISBN: 978-94-034-1660-1 (digital version)
Developing e-health applications to promote a
patient-centered approach to medically unexplained symptoms
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 3 juli 2019 om 16.15 uur
door
Anne van Gils
geboren op 7 december 1986 te Rotterdam
Promotores
Prof. dr. J.G.M. Rosmalen Prof. dr. R.A. Schoevers
Beoordelingscommissie
Prof. dr. R.C. Oude Voshaar Prof. dr. T.K. Bouman Prof. dr. H.E. van der Horst
CONTENTS
Chapter 1 General introduction 7
Part I: Development of an online course for healthcare providers
Chapter 2 User experiences of an online, interprofessional course on medically unexplained symptoms: a pilot study.
23
Part II: Development and effectiveness of self-help interventions
Chapter 3 Self-help for medically unexplained symptoms: a systematic review and meta-analysis.
41
Chapter 4 Mild traumatic brain injury management: a guide to clinical assessment and a new self-help website www.headinjurysymptoms.org.
63
Chapter 5 Development of ‘Grip self-help’: an online patient-tailored self-help intervention for functional somatic symptoms in primary care.
85
Chapter 6 Personalized, internet-based, guided self-help for patients with medically unexplained symptoms: design of a randomized controlled trial in primary care.
105
Part III: From psychosocial risk factors to potential targets for personalized treatment
Chapter 7 Family disruption increases functional somatic symptoms in late adolescence: the TRAILS study.
125
Chapter 8 Sexual abuse predicts functional somatic symptoms: an adolescent population study.
143
Chapter 9 Individual variation in temporal relationships between stress and functional somatic symptoms.
157
Chapter 10 Exploring interrelationships among worrying, anxiety, and somatic
symptoms using time-series analysis.
177
Chapter 11 General discussion 193
Summary 207
Samenvatting 213
Dankwoord 219
About the Author 221
List of Publications 222
Promotores
Prof. dr. J.G.M. Rosmalen Prof. dr. R.A. Schoevers
Beoordelingscommissie
Prof. dr. R.C. Oude Voshaar Prof. dr. T.K. Bouman Prof. dr. H.E. van der Horst
CONTENTS
Chapter 1 General introduction 7
Part I: Development of an online course for healthcare providers
Chapter 2 User experiences of an online, interprofessional course on medically unexplained symptoms: a pilot study.
23
Part II: Development and effectiveness of self-help interventions
Chapter 3 Self-help for medically unexplained symptoms: a systematic review and meta-analysis.
41
Chapter 4 Mild traumatic brain injury management: a guide to clinical assessment and a new self-help website www.headinjurysymptoms.org.
63
Chapter 5 Development of ‘Grip self-help’: an online patient-tailored self-help intervention for functional somatic symptoms in primary care.
85
Chapter 6 Personalized, internet-based, guided self-help for patients with medically unexplained symptoms: design of a randomized controlled trial in primary care.
105
Part III: From psychosocial risk factors to potential targets for personalized treatment
Chapter 7 Family disruption increases functional somatic symptoms in late adolescence: the TRAILS study.
125
Chapter 8 Sexual abuse predicts functional somatic symptoms: an adolescent population study.
143
Chapter 9 Individual variation in temporal relationships between stress and functional somatic symptoms.
157
Chapter 10 Exploring interrelationships among worrying, anxiety, and somatic
symptoms using time-series analysis.
177
Chapter 11 General discussion 193
Summary 207
Samenvatting 213
Dankwoord 219
About the Author 221
List of Publications 222
