University of Groningen
Exploring mechanisms of and therapeutic interventions for microvascular endothelial activation in shock
Yan, Rui
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Yan, R. (2019). Exploring mechanisms of and therapeutic interventions for microvascular endothelial activation in shock. University of Groningen.
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Stellingen behorende bij het proefschrift / Propositions to the dissertation
Exploring mechanisms of and therapeutic interventions
for microvascular endothelial activation in shock
1. Both systemic inflammation and local endothelial inflammatory responses as well as kidney organ damage occur in a mouse model during hemorrhagic shock and resuscitation. (This thesis)
2. Studying renal microvascular compartment phenotypes plays an important role in understanding the molecular basis for basic phenotypic heterogeneity, as well as for the heterogeneity in pathophysiological responses during kidney injury. (This thesis)
3. The endothelium in different renal microvascular segments displays different responses to disease stimuli and drug intervention in mice subjected to hemorrhagic shock and resuscitation. (This thesis)
4. Hemorrhagic shock and resuscitation disturbs the balance of the Angiopoietin-Tie2 ligand-receptor system, especially in the glomeruli in a mouse hemorrhagic shock / resuscitation injury model. (This thesis)
5. In HUVEC, an IRF-1 mediated pro-inflammatory signaling pathway exists that specifically regulates LPS-mediated VCAM-1 expression, independent of NF-κB. (This thesis)
6. Try not to become a man of success, but rather try to become a man of value. (Albert Einstein). Similarly, one should not pursue high profile publications as a goal per se, but aim to maximize the impact of research on science and clinical practice.
7. 图难于其易，为大于其细。《道德经》
(The master of it) anticipates things that are difficult while they are easy, and does things that would become great while they are small.《Dao De Jing》
8. Do not worry about tomorrow, for tomorrow will worry about itself. Each day has enough trouble of its own. (The Bible, Matthew)
9. Life is destined to be a lonely journey, the soul can only go alone. Although you will always be accompanied, sometimes you have to face it alone.
