University of Groningen
Optimizing the treatment strategy of breast cancer
Qiu, Si-Qi
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Qiu, S-Q. (2019). Optimizing the treatment strategy of breast cancer. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Curriculum vitae
Publications
208
Curricum vitae
Curriculum vitae Personal
Name Siqi Qiu, MD
Date and place of Birth 09 March 1987, Chaozhou, China Personal email address s_patrick@163.com
Education and work experience
2015-current PhD student at University of Groningen, The Netherlands. Thesis “Optimizing the treatment Strategy of breast can-cer”.
(Supervisor: Prof. dr. E.G.E. de Vries, Prof. dr. G.M. van Dam, Dr. C.P. Schröder)
2012-2015 Resident at The Breast Center, Cancer Hospital of Shantou University Medical College, China
2005-2012 Combined Bachelor-Master’s Degree Program (Clinical Medicine) at Shantou University Medical College, China. (Supervisor: Prof. Guo-Jun Zhang)
Research line Performing translational research using animal experiments and patient materials to support the surgical de-escalation and improve the systemic treatment in breast cancer. In perticular, explore the possibility of image-guided surgery in breast conserv-ing surgery usconserv-ing tumor-targeted fluorescent optical molecular imagconserv-ing.
International visit 2015 Internship, General Medicine, John Radcliffe
Hospital-Oxford University Hospitals, Hospital-Oxford, UK Award
2017 Chinese Government Award for Outstanding Self-financed Students Abroad
PUBLICATIONS
Publication (* contribute equally)
1. Qiu SQ, Dorrius MD, de Jongh SJ, Jansen L, de Vries J, Schröder CP, Zhang GJ, de Vries EGE, van der Vegt B, van Dam GM. Micro-computed tomography (micro-CT) for intraoperative surgical margin assessment of breast cancer: a feasibility study in breast conserving surgery. Eur J Surg Oncol. 2018 Nov;44(11):1708-1713.
2. Koller M*, Qiu SQ*, Linssen MD, Jansen L, Kelder W, de Vries J, Kuithof I, Zhang GJ, Robinson DJ, Nagengast WB, Jorritsma-Smit A, van der Vegt B, van Dam GM. Implementation and Benchmarking of a Novel Analytical Framework for the Clinical Evaluation of Tumor-specific Tracers for Fluorescence-guided Surgery. Nat Commun. 2018 Sep 18;9(1):3739.
3. van Rooijen JM, Qiu SQ, Timmer-Bosscha H, van der Vegt B, Boers JE, Schröder CP, de Vries EGE. Androgen receptor expression inversely correlates with immune cell infiltration in HER2-positive breast cancer. Eur J Cancer. 2018 Sep 9;103:52-60. 4. Qiu SQ*, Waaijer S*, Zwager MC, de Vries EGE, van der Vegt B, Schröder CP.
Tu-mor-associated macrophages in breast cancer: innocent bystander or important player? Cancer Treat Rev. 2018 Aug 28;70:178-189.
5. Bense RD, Qiu SQ, de Vries EGE, Schröder CP, Fehrmann RSN. Considering the bio-logy of late recurrences in selecting patients for extended endocrine therapy in bre-ast cancer. Cancer Treat Rev. 2018 Jul 26;70:118-126.
6. Qiu SQ*, Aarnink M*, van Maaren MC, Dorrius MD, Bhattacharya A, Veltman J, Kla-zen CAH, Korte JH, Estourgie SH, Ott P, Kelder W, Zeng H-C, Koffijberg H, Zhang GJ, van Dam GM, Siesling S. Validation and update of a lymph node metastasis predicti-on model for breast cancer. Eur J Surg Oncol. 2018 May;44(5):700-707.
7. Qiu SQ, Zhang GJ, Jansen L, de Vries J, Schröder CP, de Vries EGE, van Dam GM. Evolution in sentinel lymph node biopsy in breast cancer. Crit Rev Oncol Hematol. 2018 Mar;123:83-94.
8. Qiu SQ*, Zeng HC*, Zhang F, Chen C, Huang WH, Pleijhuis RG, Wu JD, van Dam GM, Zhang GJ. A nomogram to predict the probability of axillary lymph node metastasis in early breast cancer patients with positive axillary ultrasound. Sci Rep. 2016 Feb 15;6:21196.
9. Qiu SQ*, Wei XL*, Huang WH, Wu MY, Qin YS, Li YK, Zhang GJ. Diagnostic and thera-peutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma. Sci Rep. 2013;3:2529.
10. Venema CM, Bense RD, Steenbruggen TG, Nienhuis HH, Qiu SQ, van Kruchten M, Brown M, Tamimi RM, Hospers GAP, Schröder CP, Fehrmann RSN, Elisabeth de Vries EGE. Consideration of breast cancer subtype in targeting the androgen receptor. Accepted by Pharmacol Ther.
212
Dankwoord (acknowledgements)
How time files! My four-year PhD journey is coming to the end. Four years seems to be a long period, but it is short if you have a warm and supportive working environment. In the past four years, I have received so many help, encouragement and love from my dear supervisors, friends and family. Without you, I would never have come this far with my PhD study. Now it is apt time to express my sincere gratitude to all of you.
First and foremost, I would like to express my sincerest and utmost appreciation to my promotores prof. dr. E.G.E. de Vries and prof. dr. G.M. van Dam, co-promotor dr. C.P. Schröder and my Chinese supervisor prof. dr. Guo-Jun Zhang.
Dear Liesbeth, thank you for offering me this brilliant opportunity to be a member of the imaging group. Your passion and interest in science is very inspiring to me. Your critical attitude towards research always motivates me to push myself harder and do better. I truly appreciate your insightful guidance and constructive comments on my studies. This is instrumental for keeping my PhD projects on track and the completion of my thesis. Besides the scientific field, you are so supportive and very kind to my personal life and my family, and I would like to give my heartfelt acknowledgement on this. You are concerned about my academic future after I go back to China and are always willing to help me develop my career. Although you are a super busy person, you spent a whole day, together with Jan, providing Tiantian and me a special and memorable experience of Giethoorn visit in a “typical Dutch way”. This is so impressive and is something I will cherish for life-long.
Dear Go, thank you for bringing me into the world of fluorescence. I really like the discus-sion with you. You are always enthusiastic in the field of fluorescent image-guided surge-ry and have many innovative research ideas, which are vesurge-ry inspiring and helpful to me. I am deeply impressed by your energy, your passion to science and your rigorous scientific thinking. It is always great to have your valuable scientific inputs for my PhD research. Without your help, I could not have completed my thesis at this moment. Thank you for your great support. Besides the scientific field, I enjoyed a lot in the annual barbeque and new year dinner held in your house. The food is always very tasty. Your speech is always very encouraging and humorous. Indeed, there is a lot of fun to be together with the OMIG group. Thank you for your kind hospitality and the warmth of you, your wife and your children.
Dear Carolien, special thanks for your input to improve the quality of the manuscripts. I learned a lot from you. The backbones you created for the manuscripts are always so well structured. It is also very impressive to me that you can always make a sentence shorter, more precise and more clear. I often receive your working emails on the week-ends. I duly respect your enthusiasm for science, research and work and your responsi-ble attitude towards your students.
Dear Prof. Zhang, it has been my dream for many years to pursue a PhD degree abroad.
Dankwoord (acknowledgements)
I would like to express my sincere gratitude to you for helping me make this come true. Since 2010 when I started my Master study, you have encouraged me to seek opportuni-ty to study abroad after Master period. It is your insightful guidance and encouragement make me move further on this right way. Besides, your passion in the research area of fluorescent image-guided surgery and your rigorous scientific thinking impress me deeply. This also inspires me to focus my research interest on this area after my PhD study.
I extend my acknowledgement to Dr. Hetty Timmer-Bosscha. Dear Hetty, I sincerely ap-preciate your help in all aspects during my PhD study. You were easily approachable to answer my queries. You were always patient and supportive. Thanks a lot for cheering me up when I was down. I will always motivate myself by thinking of the phrase you always told me “It could be worse”.
I would like to express my acknowledgements to the members of the reading commit-tee, Prof. L.P. Stassen, Prof. S. de Jong and Prof. H. Hollema. Thank you for your efforts in evaluating my thesis.
I am indebted to all the co-authors and collaborators who contributed to this thesis. Firstly, my heartfelt appreciation to Dr. Bert van der Vegt. Dear Bert, you are listed as a co-author in 4 out of the 7 papers included in this thesis. This tells how important and supportive you are for my PhD projects. You are always so friendly to me and very patient to answer my questions. Thanks a lot for your supervision in the analysis of the tumor histopathology which is very important for chapter 5 and chapter 6. My sincere gratitude to Dr. Monique D. Dorrius for helping out with the analysis of the ultrasound images for chapter 4 and the micro-CT images for chapter 5. In addition, thanks for the produc-tive discussions, which helped me a lot for the data analysis in these two chapters. My profound gratitude to Dr. Jakob de Vries and Dr. Liesbeth Jansen for their constructive comments for chapter 2, as well as your tremendous help for the MARGIN study as re-ported in chapter 6. Special thanks to Jaap and Wilma for their hospitality. Tiantian and I enjoyed a lot in the Friesland visit. I would like to express my great appreciation to Prof. Sabine Siesling for establishing the collaboration to validate the model for predicting the risk of axillary lymph node metastasis, which resulted into a successful publication as chapter 4. Thank you very much for your constructive comments and suggestions re-garding the data analysis and manuscript preparation. My sincere gratitude also goes to Dr. Wouter B. Nagengast. Your courage to explore the unknown area is very inspiring. I really like to listen to your comments, suggestions and discussions in the OMIG meeting, which are always very insightful and constructive. I learned a lot from you. My heartfelt
214
Dankwoord (acknowledgements)
of late recurrence in ER+ breast cancer patients and the functions of AR in breast cancer. Your trust on me really means a lot to me. Thank you for sharing your knowledge and the constructive discussions. My sincere gratitude to Dr. Marco de Bruyn for his supervision on the multi-color fluorescent staining and the subsequent analysis on the images. My sincere appreciation also goes to Dr. Linda de Munck from IKNL and Dr. Coralie Poncet from EORTC for helping me out with patient data collection.
I would like to express my profoundest gratitude to Marjory, Stijn, Huancheng, Merel, Marissa, Frans, Arka, Rico, Johan, Mieke and Rick for their great contributions that re-sulted into several successful publications and several papers in preparation. You are smart, open-minded and supportive. It is our mutual understanding and helping each other attitude that has made our collaboration went so smoothly. I learnt knowledge of optical imaging from Marjory, macrophages from Stijn, skills for animal experiments from Frans, statistical analysis from Arka and biology of breast cancer late recurrence from Rico. I always cherish the time spent with Marjory for performing tracer injection for patients during the weekend, the time spent with Frans at the CDP, the time spent with Rick to add our predictive models into the online platform, and the time spent with you to discuss the data collection, data analysis, or manuscript writing. I wish all of you a bright future in your professional and personal life.
My sincere compliments also go to all the members in the imaging group and the OMIG group: Steven (de Jongh), Matthijs, Pieter, Floris, Xiaojuan, Jolien, Elmire, Iris (Schmidt), Wouter (Hooghiemstra), Lydian, Bobby, Pascal, Boudewijn, Jouke, Madelon, Judith, Ru-ben, Jasper, Wido, Marijke, Danique, Elly, Linda (Pot), Linda (Broer), Laura, Iris (Kok), Jahlisa, Martin, Thijs and Hilde. Your constructive discussions, comments and suggesti-ons after every presentation make this meeting very meaningful. Especially Steven and Floris, supermen, you always have so many helpful comments on any topic ☺ . Thank you all of you for sharing your brilliance and insights. I deeply feel that I am so lucky to be a member of the team.
I also would like to acknowledge Wytske, Linda (Pot), Annechien, Gert Jan, Erik, Marco, Jelle, Maaike, Astrid and Anita for their technical support for my PhD studies; Emma, Sharon and Oumaima for their help in processing the FFPE tissue for the MARGIN study. I would like to express my acknowledgements to the administrative support from Medi-cal Oncology department: Anouk, Coby, Gretha, Hilda and Tine. Without your help, my PhD study could not have run so smoothly.
I am thankful to my former and current officemates: Tushar, Kleber, Anne, Arka, Natha-lie, Stijn, Frans and Danique. Thank you for providing a friendly atmosphere in our office.
Dankwoord (acknowledgements)
I am very happy to share the office with you and really enjoyed the great time spent with you.
I would like to thank other former and current MOL members. Although I spent very lit-tle time in the lab during my PhD study, I can feel your friendliness and your willingness to help when necessary. Special thanks to Arjan and Rolf for their help with the thesis layout design.
I would like to acknowledge the China Scholarship Council (CSC) for conferring me “the 2017 Chinese Government Award for Outstanding Self-finance Students Abroad”. My deep acknowledgement to the Joint PhD Program between University Medical Center Groningen (UMCG)/University of Groningen and Shantou University Medical College (SUMC)/Shantou University for helping me get the PhD position at UMCG. My sincerest appreciation to Prof. dr. Folkert Kuipers and Dr. Martin Smit for their generous help in initiating my application for the PhD position. My profoundest gratitude to Dr. Frieda Law for her constant support and concern in both my study and personal life. Dear Frie-da, we know with each other for many years. How lucky I am to have your support, en-couragement and blessing at many important moments in my life. I deeply admire your dedication to the development of SUMC and medical education and your caring attitude towards your students in both of their professional and personal life.
Utmost thankfulness to Frans and Yuanke for accepting the invitation to be my para-nymphs and providing me vigorous support.
My deepest thanks to Yiwei and Huancheng for helping me out with taking care of the tedious paperwork during my study abroad.
Many thanks to my friends from SUMC: Wu Rui, Kunliang, Zhiqiang, Suping, Mingzan, Zeng Xiang, Xueting, Dong wei, Lei Yu, Jiacong, Yuanke, Dandan, Meng Pei, Xiaojian, Congzhuo, Jiang Qiong, Li Shang, Zhijun, Meifang, Ma Jie, Minghui and Zhang Yu. We help with each other and often get together to celebrate important traditional Chinese festivals like a big family. I am very happy and thankful to have your company, which ma-kes our life (Tiantian, myself and Xiaoman) in abroad have more fun and colorful. I also would like to express my gratitude to other friends: Li Na, He Yuan, Liqiang, Yuan-yuan, Hailong, Zhiqing, Sun Jing, Jiaying, Xiaodong, Baojie, Wang Peng, Congcao, Xiao-ming, Huatang, Jiawen, Miaozhen, Cao Qi, Jasmine, Huifang, Fubiao, Zhao Xin, Peijia, Keni, Wang Min, Wang Lu, Wangzhao, Yifei, Yihui and Yu Yi. My deepest gratitude to the
216
Dankwoord (acknowledgements)
always there. You are like my family in The Netherlands.
爸爸妈妈，岳父岳母，感谢你们无私的关爱、支持和奉献。没有你们作为我们坚 强的后盾，很难想象我们能按期按质完成博士学业。千言万语，也很难表达我们 的感激之情。我爱你们！感谢四姨、四丈、妹妹、妹夫、占领姐夫及其他亲戚对 我们的帮助和支持。有你们的陪伴，我们在追求梦想的道路上更加踏实和放心。 谢谢你们！
My dear daughter Xiaoman, thank you for bringing us so much fun every day. Words can’t express my love to you. Papa and Mummy hope you grow up happily and healthily. Dear Tiantian, my best half, life wouldn’t be so colorful and meaningful without your company. You are my true love, friend and mentor. Being in the same profession, I am so happy that we can understand with each other about working on weekends. We are able to share the upset at setback moments and the delightfulness when we got success in our research. When I am confused, your comfort always makes me feel confident and gives me energy to move on. I genuinely appreciate your understanding, support and encouragement to me and all of your love to the family.
My sincere apologies to those I have unintentionally missed in this section. Siqi Qiu
22-2-2019
