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University of Groningen

Optimizing the treatment strategy of breast cancer

Qiu, Si-Qi

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Qiu, S-Q. (2019). Optimizing the treatment strategy of breast cancer. Rijksuniversiteit Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Optimizing the treatment

strategy of breast cancer

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Qiu, S

Optimizing the treatment strategy of breast cancer

Thesis, University of Groningen, Groningen, The Netherlands

Printing of this thesis was financially supported by the University of Groninge, the Graduate School of Medical Sciences and the Stichting Werkgroep Interne Oncologie, UMCG.

Cover Siqi Qiu

Layout Siqi Qiu

Printed by Ridderprint

ISBN: 978-94-034-1401-0

ISBN (electronic version): 978-94-034-1400-3 © 2019, S Qiu

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without prior written permission of the author.

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Optimizing the treatment strategy

of breast cancer

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the prof. dr. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on

Wednesday 1 May 2019 at 14.30 hours

by

Siqi Qiu

born on 9 March 1987 in Guangdong, China

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Promotores

Prof. dr. E.G.E. de Vries Prof. dr. G.M. van Dam

Copromotor Dr. C.P. Schröder Assessment Committee Prof. dr. L.P. Stassen Prof. dr. S. de Jong Prof. dr. H. Hollema

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Dedicated to My Family

谨以此书献给我亲爱的家人

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Paranymphs

Frans Suurs Yuanke Liang

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CONTENTS

Chapter 1 General introduction 9

Chapter 2 Evolution in sentinel lymph node biopsy in breast cacer

Crit Rev Oncol Hematol. 2018;123:83-94 17

Chapter 3 A nomogram to predict the probability of axillary lymph node metastasis in early breast cancer patients with positive axillary ultrasound

Sci Rep. 2016;6:21196

49

Chapter 4 Validation and update of a lymph node metastasis prediction model for breast cancer

Eur J Surg Oncol. 2018;44(5):700-707

71

Chapter 5 Micro-computed tomography (micro-CT) for intraoperative surgical margin assessment of breast cancer: a feasibility study in breast conserving surgery

Eur J Surg Oncol. 2018;44(11):1708-1713

89

Chapter 6 Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

Nat Commun. 2018;9(1):3739

105

Chapter 7 Tumor-associated macrophages in breast cancer: Innocent bystander or important player?

Cancer Treat Rev. 2018;70:178-189

131

Chapter 8 Androgen receptor expression inversely correlates with immune cell infiltration in human epidermal growth factor receptor 2-positive breast cancer

Eur J Cancer. 2018;103:52-60

161

Chapter 9 Summary and future perspectives 177

Chapter 10 中文总结与展望 (Chinese summary) 189

Chapter 11 Nederlandse samenvatting (Dutch summary) 199

Curriculum vitae 208

Publications 209

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