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University of Groningen

Presentation and treatment of biliary atresia Witt, Mauri

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Witt, M. (2018). Presentation and treatment of biliary atresia. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Presentation and treatment

of biliary atresia

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ISBN: 978-94-034-1058-6 (printed version) ISBN: 978-94-034-1057-9 (electronic version)

Financial support for this thesis was kindly provided by: Vakgroep Spoedeisende Geneeskunde Isala, Fiscaal adviesbureau mr. J. Voerman, Noord Negentig, Chipsoft, Erbe B.V., University of Groningen, University Medical Center Groningen, Zeldzame Ziekten Fonds, UMCG Doelmatigheidsfonds, Astellas Pharma B.V., Hypotheekvisie Zwolle Frank van Eijk

Their support is gratefully acknowledged. Cover design: Jorn Lemmen & Mauri Witt Layout: Loes Kema

Printed by: GVO drukkers & vormgevers B.V.

Copyright © Mauri Witt, Zwolle the Netherlands 2018

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form without written permission of the author.

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Presentation and treatment

of biliary atresia

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op

maandag 26 november 2018 om 16.15 uur door

Mauri Witt

geboren op 5 september 1989 te Rotterdam

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Promotores Prof. dr. J.B.F. Hulscher Prof. dr. H.J. Verkade Beoordelingscommissie Prof. dr. R.J. Porte Prof. dr. E. Heineman Prof. dr. E.H.H.M. Rings

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Paranimfen

Drs. M.R. de Jong Drs. R.J. Dost

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CONTENTS

CHAPTER 1 Introduction and outline of the thesis 11 CHAPER 2 Early detection of neonatal cholestasis: inadequate

assessment of stool colour by parents and youth healthcare doctors.

Eur J Pediatr Surg 2016 Feb;26(1):67-73.

29

CHAPTER 3 Prophylactic Dosing of Vitamin K to Prevent Bleeding

Pediatrics 2016 May;137(5):10.1542/peds.2015-4222. 43

CHAPTER 4 Prognosis of biliary atresia after initial presentation with vitamin K deficiency bleeding.

Submitted

55

CHAPTER 5 Variceal Bleeds in Patients with Biliary Atresia

Eur J Pediatr Surg 2017 Jun 28. 69

CHAPTER 6 Prognosis of Biliary Atresia after two-year Survival with Native Liver: a Nationwide Cohort Analysis.

J Pediatr Gastroenterol Nutr. 2018 Aug 8.

83

CHAPTER 7 Summary, general discussion and future perspectives 97

Nederlandse samenvatting 107

Dankwoord 115

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