Transfusion-related acute lung injury : etiological research and its methodological challenges
Middelburg, R.A.
Citation
Middelburg, R. A. (2011, January 19). Transfusion-related acute lung injury : etiological research and its methodological challenges. Retrieved from https://hdl.handle.net/1887/16345
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Transfusion-related acute lung injury
Etiological research and its methodological challenges
Rutger A. Middelburg
The work described in this thesis was performed at the department of Clinical
Epidemiology of the Leiden University Medical Center in Leiden, the Netherlands and the department of Research and Training of Sanquin Blood Bank South West region in Leiden, the Netherlands.
Financial support for the printing of this thesis by Abbott Diagnostics, DiaMed Benelux, Hemocue Diagnostics, Terumo Europe, and the J.E. Jurriaanse Stichting is gratefully acknowledged.
ISBN: 978-94-90371-46-3 Printing: Off Page, Amsterdam
Copyright © 2010 R.A. Middelburg
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of publications.
Transfusion-related acute lung injury
Etiological research and its methodological challenges
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties ter verdediging op woensdag 19 januari 2011
klokke 16:15 uur door
Rutger Anton Middelburg
geboren te Voorschoten in 1978
Promotiecommissie
Promotor: Prof. dr. E. Briët Copromotor: Dr. J.G. van der Bom Overige leden: Prof. dr. A. Brand
Prof. dr. A.W. Hoes (Utrecht University)
Prof. N. Heddle (McMaster University, Hamilton, Canada)
Table of contents
Chapter 1 Introduction 7
Chapter 2 The role of donor antibodies in the pathogenesis of 17 Transfusion-related acute lung injury. A systematic review.
Transfusion 2008; 48: 2167-76
Chapter 3 Blood transfusions: good or bad? Confounding by indication, 39 an underestimated problem in clinical transfusion research.
Transfusion 2010; 50: 1181-3
Chapter 4 A solution to the problem of studying blood donor related risk 47 factors when patients have received multiple transfusions.
Transfusion 2010; 50: 1959-66
Chapter 5 Female donors and transfusion-related acute lung injury. 71 A case-referent study from the International TRALI Unisex
Research Group.
Transfusion 2010; Epub ahead of print
Chapter 6 No association of allo-exposed blood donors with transfusion- 89 related acute lung injury after transfusion of plasma poor product.
A case-referent study.
Submitted
Chapter 7 TRALI prevention: effectiveness of using male-only fresh 107 frozen plasma.
Transfusion 2010; In press
Chapter 8 Prevalence of leukocyte antibodies in the Dutch donor 121 population.
Vox Sanguinis 2010; Epub ahead of print
Chapter 9 Discussion 141
Summary 153
Samenvatting (Dutch summary) 157
Dankwoord 161
Publicatielijst (List of publications) 165
Curriculum Vitae 169
