Release characteristics of cardiac proteins after reversible or irreversible myocardial damage
Hessel, M.H.M.
Citation
Hessel, M. H. M. (2008, February 7). Release characteristics of cardiac proteins after reversible or irreversible myocardial damage. Retrieved from
https://hdl.handle.net/1887/12593
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12593
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Release characteristics of cardiac proteins after reversible or irreversible
myocardial damage
Marleen H M Hessel
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The research described in this thesis was performed at the department of Cardiology of the Leiden University Medical Center, Leiden, The Netherlands.
Cover: Ponsen & Looijen
Lay-out: Marleen H. M. Hessel
Printed by: Ponsen & Looijen
ISBN: 978-90-6464-211-1
Copyright © 2008 Marleen H. M. Hessel, Leiden, The Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without prior permission of the author.
Release characteristics of cardiac proteins after reversible or irreversible myocardial damage
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
ter verdediging op donderdag 7 februari 2008
klokke 13.45 uur
door
Marleen Hanne Marieke Hessel
geboren te Utrecht in 1978
4
Promotiecommissie
Promotor: Prof. dr. A. van der Laarse
Co-promotores: dr. P. Steendijk dr. D.E. Atsma
Referent: Prof. dr. W.J. van der Giessen (ErasmusMC, Rotterdam)
Overige leden: Prof. dr. E.E. van der Wall Prof. dr. R.E. Poelmann Prof. dr. ir. L.M. Havekes
Prof. dr. M.P. van Dieijen-Visser (AZMaastricht)
The research described in this thesis was supported by a grant of the Netherlands Heart Foundation (grant nr. 2001B124).
Financial support by the Netherlands Heart Foundation for publication of this thesis is gratefully acknowledged.
Voor mijn ouders
Aan Huib
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Table of Contents
Chapter 1 General introduction 9
Chapter 2 Partial and delayed release of troponin-I compared with the release 33 of lactate dehydrogenase from necrotic cardiomyocytes.
Pflügers Archiv- Eur J Physiol 2004;448:146-152
Chapter 3 Release kinetics of intact and degraded cardiac troponin I and T 51 after irreversible cardiomyocyte damage.
Submitted
Chapter 4 Release of cardiac troponin I from viable cardiomyocytes is 71 mediated by integrin stimulation.
Pflügers Archiv- Eur J Physiol 2007; in press
Chapter 5 Serum troponin concentrations in patients with congestive heart 91 failure are stretch-dependent.
Chapter 6 Characterization of right ventricular function after monocrotaline- 101 induced pulmonary hypertension in the intact rat.
Am J Physiol Heart Circ Physiol 2006;291:2424-2430
Chapter 7 Pressure overload-induced right ventricular dilatation is 123 associated with re-expression of myocardial tenascin-C
and elevated plasma levels of tenascin-C.
Submitted
Chapter 8 Reverse ventricular remodeling after cardiac resynchronization 145 therapy is associated with a reduction in serum tenascin-C and
plasma matrix metalloproteinase-9 levels.
Eur J Heart Failure 2007;9 (10):1058-1063
Chapter 9 General discussion 161
Chapter 10 Summary&Samenvatting 177
Abbreviations 191
List of publications 195
Dankwoord 199
Curriculum Vitae 203
Full color figures 205
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