Manipulating serotonin function in depression
Merens, W.
Citation
Merens, W. (2007, December 6). Manipulating serotonin function in depression. Department of Psychology/ Clinical, Health and
Neuropsychology, Faculty of Social and Behavioural Sciences, Leiden University. Retrieved from https://hdl.handle.net/1887/12478
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12478
Note: To cite this publication please use the final published version (if applicable).
Manipulating serotonin function
in depression
Merens, Wendelien
Manipulating serotonin function in depression Thesis Leiden University
ISBN 978-90-8891-0173
Cover design: Joost van der Kuil
Friesland Foods Domo financially supported publication of this thesis.
The research reported in this thesis was facilitated by research grant no. 904-57-132 from the Netherlands Organisation for Scientific Research- Medical Sciences (NWO- MW) to professor dr. A.J.W. van der Does and by the foundation ‘Stichting tot Steun VCVGZ’.
No part of this book may be reproduced in any from or by any means without written permission from the author.
Manipulating serotonin function in depression
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 6 december 2007 klokke 16:15 uur
door
Wendelien Merens geboren te Delft
in 1977
Promotiecommissie:
Promotores: Prof. dr. A. J. W. van der Does
Prof. dr. Ph. Spinhoven
Referent: Prof. dr. W.J. Riedel
Overige leden: Prof. dr. F.G. Zitman
Dr. P.M.J. Haffmans
Het leven heeft misschien geen zin, maar ik toevallig wel
(Maarten van Roozendaal)
Contents
Chapter 1: Introduction 9
Chapter 2: Residual cognitive impairments in remitted depressed 23
patients
Chapter 3: Diet rich in alpha-lactalbumin improves memory 49 in unmedicated recovered depressed patients and
matched controls
Chapter 4: The effects of a diet enriched with alpha-lactalbumin 75 on mood and cortisol response in unmedicated
recovered depressed subjects and controls
Chapter 5: The effects of experimentally lowered serotonin 101 function on emotional information processing and
memory in remitted depressed patients
Chapter 6: Low-dose tryptophan depletion and inter- 131 individual variations in tryptophan levels following
ATD
Chapter 7: The effects of acute tryptophan depletion on 139 heart rate variability
Chapter 8: The effects of serotonin manipulations on 161
emotional information processing and mood Chapter 9: Discussion 203
References 229
Samenvatting 253
Dankwoord 263
Curriculum vitae 269
Publications 271
