Snoep, J.D.
Citation
Snoep, J. D. (2011, February 16). Platelet reactivity and cardiovascular events.
Retrieved from https://hdl.handle.net/1887/16498
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PLATELET REACTIVITY AND CARDIOVASCULAR EVENTS
J.D. Snoep
Cover painting: “Lichtval” by Baldin, 2010;
Galerie Frederiek van der Vlist, Leiden
Printed on 100% recycled and chlorine-free bleached paper.
Copyright © 2011 by J.D. Snoep, Leiden.
All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
PLATELET REACTIVITY AND CARDIOVASCULAR EVENTS
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 16 februari 2011
klokke 16.15 uur
door
Jacob Daniël Snoep
geboren te Rotterdam in 1984
Promotor: Prof. dr. F.R. Rosendaal Copromotor: Dr. J.G. van der Bom
Oveige leden: Prof. dr. Ph.G. de Groot (Universiteit Utrecht) Prof. dr. J.W. Jukema
Dr. M.V. Huisman
The work described in this thesis was performed at the departments of Clinical Epidemiology and Internal Medicine/Endocrinology, section Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Studies published in this thesis were supported by grants from the Netherlands Heart Foundation (grants 92.345, 97.063 and 2003B248) and the Leducq Foundation, Paris, France for the development ofTransatlantic Networks of Excellence in Cardiovascular Research(grant 04 CVD 02).
Financial support for the publication of this thesis by the J.E. Jurriaanse Foundation, Accumetrics Inc., AstraZeneca BV, Beckman Coulter Nederland BV, Corgenix Medical Corporation, GlaxoSmithKline BV, Kordia BV, MSD, NovoNordisk BV, Roche Diagnostics Nederland BV, Servier Nederland Farma BV, and Siemens Healthcare Diagnostics is gratefully acknowledged.
Chapter 1 Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
Chapter 10 Addendum
CONTENTS
General introduction 9
Prevalence of persistent platelet reactivity
despite use of aspirin: A systematic review 19 Association of laboratory-defined aspirin resistance
with a higher risk of recurrent cardiovascular events:
A systematic review and meta-analysis 31
Clopidogrel non-responsiveness in patients undergoing percutaneous coronary intervention with stenting:
A systematic review and meta-analysis 47
Platelet reactivity in patients with stable cardiovascular disease: Correlation between different tests and
association with subject characteristics 65
Platelet reactivity and recurrent cardiovascular events in patients with stable cardiovascular disease using aspirin:
a head-to-head comparison of different tests 89 High basal platelet reactivity is associated with
myocardial infarction in premenopausal women:
A population-based case-control study 109
The T13254C-allele of GP6 is associated with decreased platelet activation and a reduced risk of recurrent
cardiovascular events and mortality 125
Time-dependent effects of low-dose aspirin on plasma
renin activity, aldosterone, cortisol and catecholamines 141
General discussion and summary 157
Samenvatting 173
Dankwoord 177
Publicatielijst 179
Curriculum Vitae 181
