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The handle http://hdl.handle.net/1887/37178 holds various files of this Leiden University dissertation

Author: Bergen, Kees van

Title: Characterization and recognition of minor histocompatibility antigens

Issue Date: 2016-01-13

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Characterization and recognition of minor histocompatibility antigens

Kees van Bergen

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ISBN: 978-94-6259-958-1

Cover illustration: Marie van Bergen-Zagers

© C.A.M. van Bergen, Den Haag, The Netherlands 2015

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Characterization and recognition of minor histocompatibility antigens

Proefschrift

ter verkrijging van

de graad van doctor aan de Universiteit Leiden op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker

volgens besluit van het College voor Promoties te verdedigen op woensdag 13 januari 2016

klokke 15:00 uur

door

Cornelis Adrianus Maria van Bergen

geboren te Zundert in 1964

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Promotor Prof.dr. J.H.F. Falkenburg Co-promotor Dr. M. Griffioen

Promotiecommissie Prof.dr. F.H.J. Claas

Prof.dr. E.C. Morris (University College London) Dr. H. Dolstra (Radboud UMC Nijmegen)

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voor Koos

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Contents

chapter 1 General Introduction and Aim of the study

chapter 2 Multiple myeloma–reactive T cells recognize an activation- induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene

chapter 3 High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning

chapter 4 Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity

chapter 5 Durable remission of renal cell carcinoma in conjuncture with graft-versus-host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?

chapter 6 T-cell response magnitude, diversity and specificity separate graft-versus-leukemia reactivity from graft-versus-host disease after allogeneic stem cell transplantation and donor lymphocyte infusion

chapter 7 Summary and General discussion

appendix Nederlandse samenvatting Dankwoord

List of publications Curriculum vitae

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57

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