Cover Page
The handle http://hdl.handle.net/1887/47911 holds various files of this Leiden University dissertation
Author: Jolink, H.
Title: Human T-cell responses to Aspergillus fumigatus: In healthy individuals and patients with Aspergillus-related disease
Issue Date: 2017-03-07
Human T-cell responses to Aspergillus fumigatus
In healthy individuals and patients with Aspergillus-related disease
Hetty Jolink
Colophon
Human T-cell responses to Aspergillus fumigatus – in healthy individuals and patients with Aspergillus- related disease
© 2017 Hetty Jolink, Langbroek
Cover: Rachel van Esschoten, DivingDuck Design (www.divingduckdesign.nl);
Illustration courtesy of James Archer (www.anatomyblue.com) Lay-out: Rachel van Esschoten, DivingDuck Design (www.divingduckdesign.nl) Printing: Ipskamp, Enschede, the Netherlands
ISBN: 978-90-9030188-4
The research described in this thesis was financially supported by Doelfonds Leukemie of the Bontius Stichting of the Leiden University Medical Center
Human T-cell responses to Aspergillus fumigatus
In healthy individuals and patients with Aspergillus -related disease
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 7 maart 2017
klokke 15.00 uur door
Hendrikje Jolink geboren te Dalfsen in 1977
Promotores:
Prof. dr. J.H.F. Falkenburg Prof. dr. J.T. van Dissel Co-promotor:
Dr. M.H.M. Heemskerk Promotiecommissie:
Prof. dr. P.S. Hiemstra Prof. dr. A. Geluk
Prof. dr. R.A.W. van Lier (Universiteit van Amsterdam) Dr. F.L. van de Veerdonk (Radboud Universiteit Nijmegen)
Contents
Chapter 1 Introduction and aim of the thesis 7
Chapter 2 Characterization of the T-cell mediated immune response 23 against the Aspergillus fumigatus proteins Crf1 and
Catalase1 in healthy individuals
Chapter 3 Induction of A. fumigatus-specific CD4+ T-cells in patients 43 recovering from invasive aspergillosis
Chapter 4 Pulmonary immune responses against Aspergillus fumigatus 73 are characterized by high frequencies of IL-17 producing T-cells
Chapter 5 Thelper2 response in allergic bronchopulmonary 91 aspergillosis is not driven by specific Aspergillus antigens Chapter 6 Phagocytosis of A. fumigatus spores by neutrophil 101
granulocytes is improved by activated CD4+ T-cells
Chapter 7 Summary 117
Addendum Nederlandse samenvatting 132
Dankwoord 138
Curriculum Vitae 140
List of abbreviations 141
List of publications 143
