University of Groningen
End-Stage Renal Disease Related Hyperparathyroidism
van der Plas, Willemijn
DOI:
10.33612/diss.151471102
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Publication date: 2021
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van der Plas, W. (2021). End-Stage Renal Disease Related Hyperparathyroidism: Towards a Patient-Tailored Journey. University of Groningen. https://doi.org/10.33612/diss.151471102
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End-Stage Renal Disease Related Hyperparathyroidism:
Towards a Patient-Tailored Journey
van der Plas, Willemijn Ytje
End-Stage Renal Disease Related Hyperparathyroidism: Towards a Patient-Tailored Journey
Design: Willemijn van der Plas
Printed by: Ridderprint - www.ridderprint.nl
The printing of this thesis was financially supported by Universitair Medisch Centrum Groningen, Graduate School of Medical Sciences, Nederlandse Transplantatie Vereniging, and Chipsoft.
© 2021 W.Y. van der Plas, Groningen, the Netherlands. All rights reserved. No part of this the-sis may be reproduced, stored in retrieval systems, or transmitted in any form by any me-ans, electronic, mechanical, photocopying, recording or otherwise without the prior writ-ten permission of the author or, when appropriate, of the publisher of the published articles.
End-Stage Renal Disease Related Hyperparathyroidism:
Towards a Patient-Tailored Journey
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 3 februari 2021 om 16.15 uur
door
Willemijn Ytje van der Plas geboren op 3 september 1994
Promotores
Prof. dr. G.M. van Dam Prof. dr. M.H. de Borst Compromotores Dr. S. Kruijff Dr. A.F. Engelsman Beoordelingscommissie Prof. dr. G.J. Navis Prof. dr. M.G. Vervloet Prof. dr. M.R. Vriens
Paranimfen S. Benjamens C.E. Vollenbrock
Ode aan de tijd
De tijd verstrijkt tot eeuwigheid Dat is voorwaar geen kleinigheid Want, mocht de wereld ooit vergaan De tijd zal steeds blijven bestaan Hij was er al voor het begin En gaat mee het oneindig in Wanneer ge meent: “er is geen tijd” Ontkent ge de realiteit Want alle leven, elk bestaan Kan door de tijd slechts verder gaan Een regelmaat verraadt zijn aard ‘t Is nooit te vroeg, laat staan te laat Al lijkt de tijd soms stil te staan Toch blijkt hij te zijn doorgegaan Soms schijnt hij zoek (waar blijft de tijd?) Toch is hij er in werk’lijkheid Een schijn van ongeregelheid Verblindt de geest, ‘ t verstand ten spijt De geest is bezig met de daad Terwijl de tijd stil verder gaat... De tijd schrijdt voort, heel ongestoord Beidt gij hem wel zo het behoort?Ytje Minderhoud - Brouwer (Oma Ytje) Wageningen, december 1981
Table of contents
Chapter 1 General introduction and outline of the thesis 10
Part I: End-stage renal disease related hyperparathyroidism
Chapter 2 Secondary and tertiary hyperparathyroidism
– a narrative review
28
Chapter 3 Association of time-updated plasma calcium and phosphate
with graft and patient outcomes after kidney transplantation 46
Part II: Surgical treatment for ESRD-related HPT
Chapter 4 Safety and efficacy of subtotal or total parathyroidectomy for
patients with secondary or tertiary hyperparathyroidism in four academic centers in the Netherlands
82
Chapter 5 Timing of parathyroidectomy does not influence renal function
after kidney transplantation
98
Chapter 6 Quality of life after surgery in secondary hyperparathyroidism,
comparing subtotal parathyroidectomy with total parathyroid-ectomy with immediate parathyroid autograft
– a prospective randomized trial
116
Chapter 7 Parathyroidectomy for patients with secondary
hyperparathy-roidism in a changing landscape for the management of end-stage renal disease
Part III: Evaluation of the role of parathyroidectomy and calcimimetics in a changing treatment algorithm of ESRD-related HPT
Chapter 8 Effect of parathyroidectomy and cinacalcet on quality of life in
patients with end-stage renal disease-related hyperparathy-roidism
– a systematic review
156
Chapter 9 Outcomes of parathyroidectomy versus calcimimetics for
sec-ondary hyperparathyroidism and kidney transplantation – a propensity matched analysis
174
Chapter 10 Impact of the introduction of calcimimetics on timing of para-thyroidectomy in secondary and tertiary hyperparathyroidism
192
Chapter 11 Treatment strategy of end-stage renal disease related
hyper-parathyroidism before, during and after the era of calcimimetics
210
Chapter 12 Changing landscape of the treatment of hyperparathyroidism related to end-stage renal disease
– can we turn the clock backward?
230
Chapter 13 Summary and general discussion Future perspectives 236 Chapter 14 Appendices 250 254 264 268 272 279 Dutch summary – Nederlandse samenvatting
List of contributing authors List of publications
Acknowledgements - Dankwoord Curriculum Vitae
