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University of Groningen Exploring combined influences of material topography, stiffness and chemistry on cell behavior at biointerfaces Zhou, Qihui

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University of Groningen

Exploring combined influences of material topography, stiffness and chemistry on cell

behavior at biointerfaces

Zhou, Qihui

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Zhou, Q. (2018). Exploring combined influences of material topography, stiffness and chemistry on cell

behavior at biointerfaces. Rijksuniversiteit Groningen.

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Exploring Combined Influences of

Material Topography, Stiffness and

Chemistry on Cell Behavior at

Biointerfaces

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Exploring Combined Influences of Material Topography, Stiffness and Chemistry on Cell Behavior at Biointerfaces

By Qihui Zhou

University Medical Center Groningen, University of Groningen Groningen, The Netherlands

Copyright © 2018 by Qihui Zhou Cover designed by Qihui Zhou

Printed by Offpage, Amsterdam, The Netherlands ISBN (printed version): 978-94-034-0780-7 ISBN (electronic version): 978-94-034-0779-1

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Exploring Combined Influences of Material

Topography, Stiffness and Chemistry on Cell

Behavior at Biointerfaces

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 11 juli 2018 om 12.45 uur

door

Qihui Zhou

geboren op 01 februari 1988

te Shandong, China

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Promotor

Prof. dr. ir. H.J. Busscher

Copromoter

Dr. P. van Rijn

Beoordelingscommissie

Prof. dr. P.Y.W. Dankers

Prof. dr. R.A. Bank

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Paranimfen:

Philipp T. Kühn

Gwenda F. Vasse

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Table of Contents

Chapter 1

General Introduction

1

Aim of the Thesis

9

Outline of the Thesis

10

Chapter 2

Mechanical Properties of Aligned Nanotopographies for

Directing Cellular Behavior

15

Chapter 3

Directing Mesenchymal Stem Cells with Gold Nanowire Arrays

37

Chapter 4

Directional Nanotopographic Gradients: a High-throughput

Screening Platform for Cell Contact Guidance

55

Chapter 5

Screening Platform for Cell Contact Guidance Based on

Inorganic Biomaterial Micro/nanotopographical Gradients

75

Chapter 6

Orthogonal Double Gradient for Determining Combined

Influences of Stiffness and Wettability on Mesenchymal Stem

Cell Behavior

101

Chapter 7 General Discussion

119

Summary

124

Samenvatting

130

Acknowledgements

136

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