University of Groningen
Influences of Complex Topography and Biochemistry on Mesenchymal Stem Cell
Differentiation
Yang, Liangliang
DOI:
10.33612/diss.146104615
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Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Yang, L. (2020). Influences of Complex Topography and Biochemistry on Mesenchymal Stem Cell Differentiation. University of Groningen. https://doi.org/10.33612/diss.146104615
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Propositions
Influences of Complex Topography and Biochemistry on Mesenchymal Stem Cell Differentiation
Liangliang Yang
1. The microenvironment that cells live in is complicated and dynamic, consisting of various physical and biochemical factors. (This Thesis)
2. High-throughput screening methods provide an ideal strategy to analyze thousands of combinations of interactions between cells and biomaterials. (This Thesis)
3. The cell aspect ratio of mesenchymal stem cells is not a determining factor for osteogenesis as was previously stated by many researchers. (Chapter 3)
4. The single cell stiffness is an important factor for topography-driven osteogenic differentiation of stem cells. (Chapter 3)
5. Via high-throughput screening methods based on topography gradients, the optimum topography for neurogenesis is easily determined and translated towards a hierarchical architecture designed to mimic the structure in nerve tissue. (Chapter 5)
6. Proper sequential repetition is a recipe for innovative hierarchical biomimetic topography. (Chapter 6)
7. When natural guidance cues are combined with powerful synthetic topography features, a synergistic effect arises for osteogenesis of mesenchymal stem cells. (Chapter 7)
8. It requires very hard work to give off an appearance of effortlessness. 9. The future of life and research is created by what you do today.
