University of Groningen
Improving quality of care for patients with ovarian and endometrial cancer
Eggink, Florine Alexandra
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2018
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Eggink, F. A. (2018). Improving quality of care for patients with ovarian and endometrial cancer.
Rijksuniversiteit Groningen.
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Improving
quality
of
care
for
patients
with
ovarian
and
endometrial cancer
Eggink, Florine Alexandra
Improving quality of care for patients with ovarian and endometrial cancer
PhD dissertation, University of Groningen, The Netherlands
ISBN electronic: 978-94-034-0283-3
ISBN printed: 978-94-034-0284-0
© Copyright 2017- Florine Eggink, Groningen, The Netherlands.
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior permission of the author or, when appropriate, the publisher of the published articles.
Cover design and layout: evelienjagtman.com
Printed by: Ridderprint BV
Printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences, Integraal Kankercentrum Nederland, Chipsoft BV, Stichting Olijf and Noord Negentig.
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 31 januari om 14.30 uur
door
Florine Alexandra Eggink
geboren op 7 september 1987 te Groningen
Promotores
Prof. dr. H.W. Nijman Prof. dr. R.F.P.M. Kruitwagen
Co-promotores
Dr. M.A. van der Aa Dr. M. de Bruyn
Beoordelingscommissie
Prof. Dr. G.A. Huls Prof. Dr. L.F.A.G. Massuger Prof. Dr. I.J.M. de Vries
Paranimfen
Dr. J.I. Kamstra Drs. F.L. Komdeur
TABLE OF CONTENTS
Chapter 1 General introduction 9
Part I: Improving organization of care for patients with ovarian cancer
Chapter 2 Improved outcomes due to changes in organization of care for patients with ovarian cancer in the Netherlands.
Gynecologic Oncology. 2016 Jun;141(3):524-30
21
Chapter 3 The impact of centralization of services on treatment delay in ovarian cancer: a study on process quality.
International Journal for Quality in Health Care. 2017 Oct 1;29(6):810-816
41
Chapter 4 Surgery for patients with newly diagnosed advanced ovarian cancer: which patient, when and extent?
Current Opinion in Oncology. 2017 Sep; 29(5):351-358
57
Part II: Improving organization of care for patients with endometrial cancer Chapter 5 Less favorable prognosis for low risk endometrial cancer patients with a
discordant pre- versus post-operative risk stratification.
European Journal of Cancer. 2017 Jun;78:82-90
77
Chapter 6 Compliance with adjuvant treatment guidelines in endometrial cancer: room for improvement in high risk patients.
Gynecologic Oncology. 2017 Aug;146(2):380-385
97
Part III: Encouraging individualization of care for patients with endometrial cancer Chapter 7 POLE proofreading mutations elicit an anti-tumor immune response in
endometrial cancer.
Clinical Cancer Research. 2015 Jul 15;21(14):3347-55
121
Chapter 8 Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
Oncoimmunology. 2016 Dec 9;6(2):e1264565
Chapter 9 Summary 183
Chapter 10 Nederlandse samenvatting voor de leek 189
Chapter 11 Discussion and perspectives 195
Appendices: List of contributing authors and affiliations 209
