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University of Groningen Macrophage-matrix interactions: orchestrating the fibrotic response? Vasse, Gwenda

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University of Groningen

Macrophage-matrix interactions: orchestrating the fibrotic response? Vasse, Gwenda

DOI:

10.33612/diss.170746933

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Vasse, G. (2021). Macrophage-matrix interactions: orchestrating the fibrotic response?. University of Groningen. https://doi.org/10.33612/diss.170746933

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Stellingen

behorende bij het proefschrift

Macrophage-matrix interactions: orchestrating the fibrotic response?

Gwenda F. Vasse

1. Macrophages have the ability to sense morphological alterations of collagen type I and change their response accordingly. (This thesis)

2. Collagens are not only more abundant in idiopathic pulmonary fibrosis, but also structurally different. (This thesis)

3. Decellularized lung matrices are suitable models to study interactions between cells and fibrosis-related structurally disrupted collagen in vitro. (This thesis)

4. Optical trapping is a powerful tool to study macrophage polarization at a single cell level. (This thesis)

5. Macrophages throughout the body should not be generalized. Location and origin matter. 6. Don’t judge macrophages solely by their cover. It’s their function that matters most. 7. Although interdisciplinary research may take you out of your comfort zone temporarily,

the resulting innovation is permanent and makes it all worthwhile.

8. ‘No one can whistle a symphony. It takes a whole orchestra to play it.’ (H.E. Luccock) 9. ‘Running and science draw on similar traits – stamina, ambition, patience, and the ability

to overcome limits.’ (W. Ketterle)

10. ‘That breath that you just took, that’s a gift.’ (R. Bell) Don’t take it for granted.

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