Type 1 diabetes, glucocorticoids and the brain: a sweet connection
Revsin, Y.
Citation
Revsin, Y. (2008, September 17). Type 1 diabetes, glucocorticoids and the brain: a sweet connection. Retrieved from https://hdl.handle.net/1887/13211
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13211
Note: To cite this publication please use the final published version (if applicable).
Propositions
1) The streptozotocin (STZ)-mice model is a good animal model to study type 1 diabetes (this thesis).
2) Timing and context are crucial for psychotropic effects of glucocorticoids on memory performance (Joëls M. et al Trends Cogn Sci. 2006: 152-158).
3) The avoidance of sex and wine prescribed as a treatment of diabetes by Dr. Li Hsuan (AD 500) lacks supporting scientific evidence.
4) Glucocorticoid excess is responsible for hippocampal disruption and cognitive impairment in the early stages of diabetes (this thesis).
5) The quality of maternal care prepares an individual for life ahead (Champagne D. et al J Neurosci.
2008: 6037-45).
6) There is nothing bubbles can’t fix.
7) In view of the profound regional differences in brain gene expression patterns, laser-guided microdissection of neuro-anatomically defined areas is required for meaningful micro-array studies (Datson NA et al Eur J Neurosci. 2004: 2541-2554)
8) Enhanced adrenal sensitivity to ACTH rather than enhanced pituitary ACTH release is the primary event producing hypercorticism in STZ-induced type 1 diabetes (this thesis).
9) It is your paper that has been rejected, not you (Edwin Gale, Editor of Diabetologia).
10) The onset of type 1 diabetes is signaled by enhanced ACTH release in the NOD mouse, an autoimmune model of the disease (this thesis).
