University of Groningen
The cardiac fetal gene program in heart failure
van der Pol, Atze
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van der Pol, A. (2018). The cardiac fetal gene program in heart failure: From OPLAH to 5-oxoproline and beyond. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Stellingen behorende bij het proefschrift
The cardiac fetal gene program in heart failure:
From OPLAH to 5-oxoproline and beyond
Atze van der Pol
1. “Characterizing the pathophysiological pathways implicated in cardiac fetal reprogramming could lead to novel therapeutic targets for heart failure.”
This thesis
2. “Oplah is a novel member of the cardiac fetal gene program.” This thesis 3. “Oplah overexpression has a cardio-protective effect in mice exposed to
ischemic heart failure, by reducing 5-oxoproline induced oxidative stress, resulting in improved cardiac function.” This thesis
4. “Complete disruption of Oplah leads to changes resembling clinical HFpEF.” This thesis
5. “Circulating 5-oxoproline, the substrate of OPLAH, has diagnostic and prognostic potential in patients with heart failure.” This thesis
6. “Bolstering the levels of endogenous GSH or increasing the activity of the γ-Glutamyl cycle may be a novel approach to dealing with oxidative stress and improving outcome of heart failure patients.” This thesis
7. “Saber más es ser más libre.” (“To know more is to be free”) César Vallejo 8. “Chance is the only source of true novelty.” Francis Crick
