Matrix metalloproteinases involvement in rheumatoid arthritis
Tchetverikov, I.
Citation
Tchetverikov, I. (2005, February 17). Matrix metalloproteinases involvement in rheumatoid
arthritis. Retrieved from https://hdl.handle.net/1887/625
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/625
Matrix Metalloproteases Involvement in
Rheumatoid Arthritis
© 2004, I. Tchetverikov, Leiden, The Netherlands
Matrix Metalloproteases Involvement in
Rheumatoid Arthritis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Dr. D. D. Breimer,
hoogleraar in de faculteit der W iskunde en
Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 17 februari 2005
te klokke 14.15 uur
door
Ilja Tchetverikov
PROMOTIECOMMISSIE
Promotores: Prof. dr. F.C. Breedveld Prof. dr. T.W.J. Huizinga Copromotor: Dr. R. Hanemaaijer
Referent: Prof. dr. M. H. van Rijswijk Overige leden: Prof. dr. M. R. Daha
Dr. J. de Groot
Mw. dr. G. Kloppenburg
Financial support by Abbot B.V., Aventis B.V., the Dr. Ir. Van de Laar Stichting, the Dutch Arthritis Association, Pfizer B.V. and TNO Pharma for the publication of this thesis is gratefully acknowledged.
“ɉɪɨɫɬɢɬɟ, ɧɟ ɩɨɜɟɪɸ,- ɨɬɜɟɬɢɥ ȼɨɥɚɧɞ,- ɷɬɨɝɨ ɛɵɬɴ ɧɟ ɦɨɠɟɬ.
Ɋɭɤɨɩɢɫɢ ɧɟ ɝɨɪɹɬ.”
(Pardon me for not believing it, - said Woland, - that is not possible.
Contents
Chapter 1 General introduction 9
Chapter 2 Active MMPs captured by alpha2Macroglobulin as a marker of 29
disease activity in rheumatoid arthritis
Clinical and Experimental Rheumatology, 2003;21(6):711-8.
Chapter 3 MMP activity measurements using low molecular weight 45 fluorogenic substrates
Submitted.
Chapter 4 MMP profile in paired serum and synovial fluid samples of 57 rheumatoid arthritis patients
Annals of Rheumatic Diseases, 2004;63(7):881-3.
Chapter 5 Matrix Metalloproteinases-3, -8, -9 as markers of disease activity 67 and joint damage progression in early rheumatoid arthritis
Annals of Rheumatic Diseases, 2003;62(11):1094-9.
Chapter 6 MMP protein and activity levels in synovial fluid of joint injury, 83 arthritis and osteoarthritis patients
Annals of Rheumatic Diseases, in press.
Chapter 7 Effects of treatment with leflunomide or methotrexate on 97 Į2Macroglobulin/MMP complexes in serum of rheumatoid
arthritis patients Submitted.
Chapter 8 Summary and general discussion 107
Appendix Nederlandse samenvatting 119
List of abbreviations 127
List of publications 129
Acknowledgments 131
