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Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity Berry, A.

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Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity

Berry, A.

Citation

Berry, A. (2010, April 21). Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity. Retrieved from https://hdl.handle.net/1887/15280

Version: Corrected Publisher’s Version License:

Licence agreement concerning inclusion of

doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15280

Note: To cite this publication please use the final published version (if applicable).

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Statements

(Stellingen) associated with the thesis

Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity

1) It is unlikely that the extended longevity of p66Shc-/-mice results from a more efficient glucocorticoid action induced by the attenuation of oxidative stress reactions

(this thesis)

2) The effects predicted by the trade-off theory of aging are blunted in laboratory settings (this thesis)

3) P66Shc-/-mice not only live longer but their health at senescence is also improved (this thesis)

4) The role of p66Shcgene in determining lifespan is not merely related to its effects on ox- idative stress but rather to its interaction with metabolic, behavioral and oxidative stress signaling cascades which are known as important determinants of healthspan

(this thesis)

5) Natural selection has shaped offspring to respond to subtle variations in parental be- haviors as a forecast of the environmental conditions they will ultimately face follow- ing independence from the parent

(R.A. Hinde, Academic Press, Orlando, 1986, pp. 13-32)

6) Aging is not only an unreasonable maladaptive epiphenomenon but is likely to be the downside of a trade-off with other fitness-enhancing traits

(Partridge L. and Gems D., Nat Rev Genet. 2002; 3:165-175)

7) The impact of the age-related breakdown of adaptation is far more disruptive when in- tegrative homeostatic communication systems are also affected

(Everitt A. and Meites J., J Gerontol. 1989; 44:B139-147)

8) Even the complex brain circuits involved in learning and memory, emotions and higher cognitive functions could be considered as having evolved as energy adaptations (Mattson M.P., Maudsley S. and Martin B., Ageing Res Rev. 2004; 3:445-464) 9) Minds are like parachutes: they only function when they’re open

(Sir Thomas Robert Dewar, Scottish whisky distiller)

foglietto interno:Layout 1 16-03-2010 15:40 Pagina 1

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