Adoptive immunotherapy after HLA mismatched stem cell
transplantation
Oosten, L.E.M.
Citation
Oosten, L. E. M. (2007, November 21). Adoptive immunotherapy after HLA
mismatched stem cell transplantation. Retrieved from
https://hdl.handle.net/1887/12446
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral
thesis in the Institutional Repository of the University
of Leiden
Downloaded from: https://hdl.handle.net/1887/12446
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Abbreviations
aAPC artifi cial antigen-presenting construct
ALL acute lymphatic leukemia AML acute myeloid leukemia APC antigen-presenting cell APhC allophycocyanin APL altered peptide ligand
CDR complementarity-determining region
CLL chronic lymphatic leukemia CML chronic myeloid leukemia CMV cytomegalovirus
CTL cytotoxic T lymphocytes DC dendritic cell
DLI donor lymphocyte infusion EBV-LCL Epstein-Barr virus-transformed
lymphoblastoid cell lines E:T effector to target ratio ER endoplasmatic reticulum FACS fl uorescence-activated cell
sorter
FITC fl ourescein isothiocyanate GFP green fl uorescent protein GMP good manufacturing practices GvHD graft-versus-host disease GvL graft-versus-leukemia HLA human leukocyte antigens HPLC high performance liquid
chromatography HS human serum IFN- interferon- IL- interleukin-
IMDM Iscove’s modifi ed Dulbecco’s medium
mAb monoclonal antibody MFI mean fl uorescence intensity mHag minor histocompatibility
antigen
MHC major histocompatibility complex
MDS myelodysplastic syndrome MM multiple myeloma NK natural killer
PBMC peripheral blood mononuclear cell
PBS phosphate-buffered saline PCR polymerase chain reaction PE phycoerythrin
PerCP peridinin chlorophyll protein PR-3 proteinase-3
SCT stem cell transplantation TAP transporter associated with
antigen-processing TCR T cell receptor Th T helper
TNF- tumor necrosis factor- UCB umbilical cord blood WT1 Wilms’ tumor antigen
